Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.
Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.
复制标题
DOI：
10.1038/mp.2017.246
复制
发表时间：
2018-03
影响因子：
11
通讯作者：
Bazinet RP
中科院分区：
文献类型：
--
作者：
Hopperton KE;Mohammad D;Trépanier MO;Giuliano V;Bazinet RP
神经炎症被认为是阿尔茨海默病病理（包括淀粉样β斑块）导致神经元死亡和功能障碍的机制之一。小胶质细胞（主要的神经免疫细胞）标记物的表达增加在阿尔茨海默病患者的大脑中被广泛报道，但文献尚未被系统地审查以确定这是否是一致的病理特征。在Medline、Embase和PsychINFO进行了系统检索，检索截至2017年2月23日发表的文章。如果论文对阿尔茨海默病患者和无神经系统疾病的老年对照者死后脑样本中的小胶质细胞标记物进行定量比较，则论文被纳入。共确定了113条有关条款。与非神经衰老对照组相比，与激活相关的标记物，如主要组织相容性复合体II（36/43项研究）和分化簇68（17/21项研究）一致增加，而其他既染色静息小胶质细胞又染色活化小胶质细胞的常见标记物，如电离钙结合接头分子1（10/20项研究）和分化簇11b（2/5项研究），并没有一致升高。使用细胞计数的电离钙结合接头分子1的研究几乎一致地发现与对照相比没有差异，这表明激活的增加发生在没有增加小胶质细胞总数的情况下。与大脑其他区域相比，白质和小脑似乎更能抵抗这种增长。九项研究确定了包括高病理对照，尽管阿尔茨海默病病理，但仍然没有痴呆症的患者。这些研究中的大多数（5/9）报告了阿尔茨海默病的小胶质细胞标志物水平高于对照组，这表明这些增加不仅仅是阿尔茨海默病病理的结果。这些结果表明，小胶质细胞标记物的增加是阿尔茨海默病的一贯特征，尽管这似乎主要是由激活相关标记物的增加所驱动的，而不是所有小胶质细胞的标记物。
Neuroinflammation is proposed as one of the mechanisms by which Alzheimer’s disease pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases in the expression of markers of microglia, the main neuroinmmune cell, are widely reported in brains from patients with Alzheimer’s disease, but the literature has not yet been systematically reviewed to determine whether this is a consistent pathological feature. A systematic search was conducted in Medline, Embase and PsychINFO for articles published up to 23 February 2017. Papers were included if they quantitatively compared microglia markers in post-mortem brain samples from patients with Alzheimer’s disease and aged controls without neurological disease. A total of 113 relevant articles were identified. Consistent increases in markers related to activation, such as major histocompatibility complex II (36/43 studies) and cluster of differentiation 68 (17/21 studies), were identified relative to nonneurological aged controls, whereas other common markers that stain both resting and activated microglia, such as ionized calcium-binding adaptor molecule 1 (10/20 studies) and cluster of differentiation 11b (2/5 studies), were not consistently elevated. Studies of ionized calcium-binding adaptor molecule 1 that used cell counts almost uniformly identified no difference relative to control, indicating that increases in activation occurred without an expansion of the total number of microglia. White matter and cerebellum appeared to be more resistant to these increases than other brain regions. Nine studies were identified that included high pathology controls, patients who remained free of dementia despite Alzheimer’s disease pathology. The majority (5/9) of these studies reported higher levels of microglial markers in Alzheimer’s disease relative to controls, suggesting that these increases are not solely a consequence of Alzheimer’s disease pathology. These results show that increased markers of microglia are a consistent feature of Alzheimer’s disease, though this seems to be driven primarily by increases in activation-associated markers, as opposed to markers of all microglia.
登录
查看更多内容
影响因子：
7.1
作者：
Bachstetter AD;Van Eldik LJ;Schmitt FA;Neltner JH;Ighodaro ET;Webster SJ;Patel E;Abner EL;Kryscio RJ;Nelson PT
通讯作者：
Nelson PT
影响因子：
2.5
作者：
AKIYAMA, H;IKEDA, K;MCGEER, PL
通讯作者：
MCGEER, PL
影响因子：
9.3
作者：
Cribbs DH;Berchtold NC;Perreau V;Coleman PD;Rogers J;Tenner AJ;Cotman CW
通讯作者：
Cotman CW
影响因子：
6.4
作者：
DeLuca, Gabriele C.;Joseph, Albert;Esiri, Margaret M.
通讯作者：
Esiri, Margaret M.
影响因子：
2.5
作者：
Bayer, TA;Buslei, R;Falkai, P
通讯作者：
Falkai, P