Menopause and cognitive impairment: A narrative review of current knowledge.
Menopause and cognitive impairment: A narrative review of current knowledge.
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DOI：
10.5498/wjp.v11.i8.412
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发表时间：
2021-08-19
影响因子：
3.1
通讯作者：
Costa-Paiva L
中科院分区：
文献类型：
--
作者：
Conde DM;Verdade RC;Valadares ALR;Mella LFB;Pedro AO;Costa-Paiva L
认知功能严重受损是痴呆症的特征。轻度认知障碍代表正常认知和痴呆之间的过渡。女性认知变化的频率高于男性。基于这一事实，荷尔蒙因素可能会导致认知能力下降。从这个意义上说，认知功能障碍在更年期附近更为常见，这是一个以激素水平（尤其是雌激素）下降为标志的阶段。此外，据报道，更年期女性的认知能力有恶化的趋势。血管舒缩症状（潮热、出汗和头晕）、阴道干燥、烦躁和健忘很常见，并与卵巢功能进行性下降和随后血清雌激素浓度降低有关。基于雌激素并加或不加孕激素的激素疗法 (HT) 是缓解更年期症状的首选治疗方法。迄今为止进行的研究报告了关于 HT 对认知的影响的相互矛盾的结果。本文综述了更年期与认知的主要方面，包括雌激素的神经保护作用以及更年期症状与认知功能之间的关系。我们介绍并讨论关于 HT 和认知的集中观察和干预研究的结果。
A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment represents a transition between normal cognition and dementia. The frequency of cognitive changes is higher in women than in men. Based on this fact, hormonal factors likely contribute to cognitive decline. In this sense, cognitive complaints are more common near menopause, a phase marked by a decrease in hormone levels, especially estrogen. Additionally, a tendency toward worsened cognitive performance has been reported in women during menopause. Vasomotor symptoms (hot flashes, sweating, and dizziness), vaginal dryness, irritability and forgetfulness are common and associated with a progressive decrease in ovarian function and a subsequent reduction in the serum estrogen concentration. Hormone therapy (HT), based on estrogen with or without progestogen, is the treatment of choice to relieve menopausal symptoms. The studies conducted to date have reported conflicting results regarding the effects of HT on cognition. This article reviews the main aspects of menopause and cognition, including the neuroprotective role of estrogen and the relationship between menopausal symptoms and cognitive function. We present and discuss the findings of the central observational and interventional studies on HT and cognition.
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DOI：
10.1097/gme.0000000000001608
发表时间：
2020-11-01
影响因子：
2.7
作者：
Fogel, Jessica;Rubin, Leah H.;Maki, Pauline M.
通讯作者：
Maki, Pauline M.
在巴西成人健康纵向研究（Elsa-Brasil）的参与者中，教育在认知测试表现中起着更大的作用。
影响因子：
2.6
作者：
de Azeredo Passos VM;Giatti L;Bensenor I;Tiemeier H;Ikram MA;de Figueiredo RC;Chor D;Schmidt MI;Barreto SM
通讯作者：
Barreto SM
影响因子：
6.3
作者：
Espeland MA;Brunner RL;Hogan PE;Rapp SR;Coker LH;Legault C;Granek I;Resnick SM;Women's Health Initiative Study of Cognitive Aging Study Group
通讯作者：
Women's Health Initiative Study of Cognitive Aging Study Group
影响因子：
4.7
作者：
Callier, S;Le Saux, M;Pelaprat, D
通讯作者：
Pelaprat, D
影响因子：
4.8
作者：
Brown, Candice M.;Mulcahey, Tara A.;Wise, Phyllis M.
通讯作者：
Wise, Phyllis M.