Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad.
Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the Physiopathological Status of the Aged Male Gonad.
复制标题
DOI：
10.3390/cells10113114
复制
发表时间：
2021-11-10
期刊：
影响因子：
6
通讯作者：
Frungieri MB
中科院分区：
文献类型：
--
作者：
Matzkin ME;Calandra RS;Rossi SP;Bartke A;Frungieri MB
衰老的进化理论支持生殖和衰老之间的权衡关系。男性生殖系统的衰老主要影响睾丸，导致性激素水平下降、精子质量和产量改变以及生育能力下降，但不一定会完全停止精子发生。炎症、氧化和细胞凋亡被认为是年龄相关疾病发病机制和发展的预测因素，这些疾病在老年睾丸中经常观察到。尽管分子机制仍知之甚少，但越来越多的证据表明促炎分子和活性氧是睾丸衰老的主要影响因素。然而，与衰老相关的睾丸改变对生育能力、生殖健康和寿命的真正影响还远未得到充分揭示。这项工作讨论了目前关于睾丸衰老影响的知识，特别是与衰老相关的炎症失调和氧化损伤对其不同细胞群功能的影响。更有趣的是，这篇综述涵盖了使用具有抗炎、抗氧化和抗凋亡特性的药理化合物（例如非选择性非甾体抗炎药物）或更天然的替代品（例如各种营养保健品甚至益生菌）进行抗衰老干预和治疗的潜在益处。其中一些目前正在研究或已经在临床中用于延缓或预防睾丸衰老。
The evolutionary theory of aging supports a trade-off relationship between reproduction and aging. Aging of the male reproductive system primarily affects the testes, leading to a decrease in the levels of sexual hormones, alterations in sperm quality and production, and a decline in fertility that does not necessarily involve a complete cessation of spermatogenesis. Inflammation, oxidation, and apoptosis are events considered as predictors of pathogenesis and the development of age-related diseases that are frequently observed in aged testes. Although the molecular mechanisms are still poorly understood, accumulating evidence points toward pro-inflammatory molecules and reactive oxygen species as primary contributing factors for testicular aging. However, the real impact of aging-related testicular alterations on fertility, reproductive health, and life span is far from being fully revealed. This work discusses the current knowledge on the impact of aging in the testis, particularly of aging-related dysregulated inflammation and oxidative damage on the functioning of its different cell populations. More interestingly, this review covers the potential benefits of anti-aging interventions and therapies using either pharmacological compounds (such as non-selective non-steroidal anti-inflammatory medication) or more natural alternatives (such as various nutraceuticals or even probiotics) that exhibit anti-inflammatory, antioxidant, and anti-apoptotic properties. Some of these are currently being investigated or are already in clinical use to delay or prevent testicular aging.
登录
查看更多内容
影响因子：
6.1
作者：
Albert, O.;Desdoits-Lethimonier, C.;Jegou, B.
通讯作者：
Jegou, B.
影响因子：
1.9
作者：
Beltran-Frutos, E.;Seco-Rovira, V.;Pastor, Luis Miguel
通讯作者：
Pastor, Luis Miguel
DOI：
10.1016/s0889-8529(03)00047-1
发表时间：
2003-09-01
影响因子：
4.5
作者：
Brugh, VM;Matschke, HM;Lipshultz, LI
通讯作者：
Lipshultz, LI
DOI：
10.29271/jcpsp.2018.07.501
发表时间：
2018-07-01
影响因子：
1
作者：
Aydin, Seval;Yanar, Karolin;Cakatay, Ufuk
通讯作者：
Cakatay, Ufuk
影响因子：
4
作者：
BARTLETT, JMS;CHARLTON, HM;NIESCHLAG, E
通讯作者：
NIESCHLAG, E