Effects of repeated ether stress on the hypothalamic-pituitary-testes axis in adult rats with special reference to inhibin secretion.
Effects of repeated ether stress on the hypothalamic-pituitary-testes axis in adult rats with special reference to inhibin secretion.
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重复乙醚应激对成年大鼠下丘脑-垂体-睾丸轴的影响，特别是抑制素分泌。
DOI：
10.1292/jvms.59.329
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
K. Taya
中科院分区：
文献类型：
--
作者：
A. Tohei;T. Tomabechi;M. Mamada;Makoto Akai;G. Watanabe;K. Taya
研究了乙醚应激对成年雄性大鼠下丘脑-垂体-性腺轴的影响。为了阐明肾上腺糖皮质激素在性腺功能中的作用，还研究了肾上腺切除术和地塞米松治疗的效果。乙醚应激增加了ACTH和皮质酮的血浆浓度，但降低了LH、FSH、抑制素和睾酮的血浆浓度。在应激大鼠中，垂体对 LH-RH 释放 LH 的反应性和睾丸对内源性 LH 释放睾酮的反应性得以维持。肾上腺切除术导致血浆ACTH浓度升高，但降低了LH、FSH和睾酮的血浆浓度。地塞米松治疗肾上腺切除大鼠后血浆促性腺激素水平恢复至对照水平。肾上腺切除大鼠的血浆抑制素浓度没有变化，但与地塞米松治疗的对照大鼠相比，血浆抑制素浓度有所降低。对完整雄性大鼠进行地塞米松治疗后，血浆睾酮和抑制素水平下降，但 LH 和 FSH 水平没有下降，表明地塞米松对睾丸有直接影响。这些结果表明，应激大鼠中 ACTH 分泌增加可能是由于下丘脑 CRH 分泌过多，从而通过抑制 LH-RH 抑制促性腺激素分泌。睾酮水平下降可能是由于应激引起的血浆 LH 浓度下降和乙醚应激大鼠皮质酮分泌增加所致。应激大鼠血浆抑制素水平低也可能是由于皮质酮对支持细胞的直接影响。
Effects of ether stress on the hypothalamo-hypophysial-gonadal axis in adult male rats were examined. To clarify the role of adrenal glucocorticoids in gonadal function, the effects of adrenalectomy and Dexamethasone treatment were also investigated. Ether stress increased the plasma concentrations of ACTH and corticosterone, but decreased the plasma concentrations of LH, FSH, inhibin and testosterone. The pituitary responsiveness to LH-RH for LH release and testicular responsiveness to the endogenous LH for testosterone release were maintained in stressed rats. Adrenalectomy caused an increase in the plasma concentrations of ACTH, but decreased the plasma concentrations of LH, FSH and testosterone. Dexamethasone treatment in adrenalectomized rats recovered the levels of plasma gonadotropins to control levels. The concentration of plasma inhibin did not change in adrenalectomized rats, but it was decreased compared to control rats by Dexamethasone treatment. Treatments of Dexamethasone in intact male rats resulted in a decline in plasma levels of testosterone and inhibin without a decrease in the levels of LH and FSH, indicating the direct effect of Dexamethasone on the testes. These results indicate that increased ACTH secretion in stressed rats is probably due to hypersecretion of CRH from the hypothalamus, which suppresses gonadotropin secretion via the inhibition of LH-RH. The decreased levels of testosterone may be caused by a stress-induced decrease in plasma LH concentrations and increased secretion of corticosterone in the ether stressed rats. The low levels of plasma inhibin in stressed rats was also probably due to the direct effect of corticosterone on the Sertoli cells.
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影响因子：
--
作者：
T. Orr;Taylor Mf;Bhattacharyya Ak;Collins Dc;David R. Mann
通讯作者：
T. Orr;Taylor Mf;Bhattacharyya Ak;Collins Dc;David R. Mann
影响因子：
4.8
作者：
BAMBINO, TH;HSUEH, AJW
通讯作者：
HSUEH, AJW
影响因子：
4.1
作者：
SWANSON, LW;SAWCHENKO, PE;VALE, WW
通讯作者：
VALE, WW
影响因子：
56.9
作者：
RIVIER, C;RIVIER, J;VALE, W
通讯作者：
VALE, W
DOI：
10.1172/jci111748
发表时间：
1985-02
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
C. Rivier;W. Vale
通讯作者：
C. Rivier;W. Vale