Acute associations between heatwaves and preterm and early-term birth in 50 US metropolitan areas: a matched case-control study.
Acute associations between heatwaves and preterm and early-term birth in 50 US metropolitan areas: a matched case-control study.
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DOI：
10.1186/s12940-021-00733-y
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发表时间：
2021-04-23
期刊：
影响因子：
--
通讯作者：
Darrow LA
中科院分区：
文献类型：
--
作者：
Huang M;Strickland MJ;Richards M;Holmes HA;Newman AJ;Garn JV;Liu Y;Warren JL;Chang HH;Darrow LA
热浪对不良出生结果的影响尚未得到很好的理解，可能会因热浪的定义而有所不同。该研究旨在研究各种热浪定义与早产和早产之间的急性关联。使用1982年至1988年50个大都市统计区（MSA）的国家生命记录，将单胎早产（< 37周）和早产（37-38周）分别与妊娠至少37周或39周的对照组进行匹配（1：1）。匹配变量为MSA、母亲种族和母亲教育程度。创建了60个热浪定义，包括暴露于持续高温的二元指标，高温天数和基于MSA特定温度指标的第97.5百分位数或正过热因子（EHF）的第85百分位数的热强度（过去7天超过阈值的平均度）的测量。使用条件Logistic回归调整母亲年龄、婚姻状况和季节性，估计出生前一周（或对照组相应的孕周）热浪暴露的比值比（OR）。评估了母亲教育、年龄、种族/民族、儿童性别和地区对效应的影响。分析中有615，329例早产儿和1，005，576例早期病例对照对。对于大多数定义，分娩前一周暴露于热浪始终与早产几率增加相关。暴露于更高的热量天和更多的程度以上的阈值产生更高的幅度OR。与零天相比，过去一周平均温度超过97.5百分位数3天或更多天，早产的OR为1.027（95%CI：1.014，1.039）。虽然我们在评估各种热浪定义和早产时通常发现零关联，但西班牙裔和非西班牙裔黑人母亲中早产和早产的OR值更大。虽然相关性在指标和热浪定义上有所不同，但热浪与早产的相关性比早产更一致。这项研究的发现可能对随着气候变化的进展针对脆弱亚群体的预防计划产生影响。在线版本包含补充材料，可通过10.1186/s12940-021-00733-y获得。
The effect of heatwaves on adverse birth outcomes is not well understood and may vary by how heatwaves are defined. The study aims to examine acute associations between various heatwave definitions and preterm and early-term birth. Using national vital records from 50 metropolitan statistical areas (MSAs) between 1982 and 1988, singleton preterm (< 37 weeks) and early-term births (37–38 weeks) were matched (1:1) to controls who completed at least 37 weeks or 39 weeks of gestation, respectively. Matching variables were MSA, maternal race, and maternal education. Sixty heatwave definitions including binary indicators for exposure to sustained heat, number of high heat days, and measures of heat intensity (the average degrees over the threshold in the past 7 days) based on the 97.5th percentile of MSA-specific temperature metrics, or the 85th percentile of positive excessive heat factor (EHF) were created. Odds ratios (OR) for heatwave exposures in the week preceding birth (or corresponding gestational week for controls) were estimated using conditional logistic regression adjusting for maternal age, marital status, and seasonality. Effect modification by maternal education, age, race/ethnicity, child sex, and region was assessed. There were 615,329 preterm and 1,005,576 early-term case-control pairs in the analyses. For most definitions, exposure to heatwaves in the week before delivery was consistently associated with increased odds of early-term birth. Exposure to more high heat days and more degrees above the threshold yielded higher magnitude ORs. For exposure to 3 or more days over the 97.5th percentile of mean temperature in the past week compared to zero days, the OR was 1.027 for early-term birth (95%CI: 1.014, 1.039). Although we generally found null associations when assessing various heatwave definitions and preterm birth, ORs for both preterm and early-term birth were greater in magnitude among Hispanic and non-Hispanic black mothers. Although associations varied across metrics and heatwave definitions, heatwaves were more consistently associated with early-term birth than with preterm birth. This study’s findings may have implications for prevention programs targeting vulnerable subgroups as climate change progresses. The online version contains supplementary material available at 10.1186/s12940-021-00733-y.
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影响因子：
10.4
作者：
Kent ST;McClure LA;Zaitchik BF;Smith TT;Gohlke JM
通讯作者：
Gohlke JM
影响因子：
10.4
作者：
Ha S;Liu D;Zhu Y;Kim SS;Sherman S;Mendola P
通讯作者：
Mendola P
影响因子：
10.4
作者：
Anderson GB;Bell ML
通讯作者：
Bell ML
影响因子：
10.4
作者：
Dadvand P;Basagaña X;Sartini C;Figueras F;Vrijheid M;de Nazelle A;Sunyer J;Nieuwenhuijsen MJ
通讯作者：
Nieuwenhuijsen MJ
影响因子：
9.8
作者：
Coris, EE;Ramirez, AM;Van Durme, DJ
通讯作者：
Van Durme, DJ