Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions.
Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions.
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DOI：
10.1038/s41423-020-0503-y
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发表时间：
2020-09
影响因子：
24.1
通讯作者：
Prinz I
中科院分区：
文献类型：
--
作者：
Deseke M;Prinz I
T淋巴细胞包含表达αβ或γδ TCR的细胞。αβ TCR如何被MHC背景下呈递的特异性肽触发的谜团不久前被阐明。相比之下，γδ TCR识别抗原的机制仍然令科学界困惑。显然，γδ TCR的活化不一定依赖于MHC抗原呈递。迄今为止，多种多样且主要来源于宿主细胞的分子已被鉴定为γδ TCR的同源抗原。然而，对于大多数γδ TCR，活化配体仍然是未知的，并且关于生理相关性和可推广的概念的许多开放性问题仍然存在。特别是γδ T细胞如何通过其TCR区分稳态和应激条件的问题在很大程度上仍未得到解决。该领域的最新发现可能为更好地理解γδ TCR的抗原识别铺平了道路，并使修改现有知识和将新发现置于背景中成为可能。
T lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs are triggered by specific peptides presented in the context of MHC was elucidated some time ago. In contrast, the mechanisms that underlie antigen recognition by γδ TCRs are still baffling the scientific community. It is clear that activation of γδ TCRs does not necessarily depend on MHC antigen presentation. To date, diverse and largely host-cell-derived molecules have been identified as cognate antigens for the γδ TCR. However, for most γδ TCRs, the activating ligand is still unknown and many open questions with regard to physiological relevance and generalizable concepts remain. Especially the question of how γδ T cells can distinguish homeostatic from stress conditions via their TCR remains largely unresolved. Recent discoveries in the field might have paved the way towards a better understanding of antigen recognition by the γδ TCR and have made it conceivable to revise the current knowledge and contextualize the new findings.
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影响因子：
5.4
作者：
DELFAU, MH;HANCE, AJ;GRANDCHAMP, B
通讯作者：
GRANDCHAMP, B
影响因子：
3.6
作者：
Aydintug MK;Zhang L;Wang C;Liang D;Wands JM;Michels AW;Hirsch B;Day BJ;Zhang G;Sun D;Eisenbarth GS;O'Brien RL;Born WK
通讯作者：
Born WK
DOI：
10.1073/pnas.1010890108
发表时间：
2011-02-22
影响因子：
11.1
作者：
Barbee, Susannah D.;Woodward, Martin J.;Hayday, Adrian C.
通讯作者：
Hayday, Adrian C.
影响因子：
15.9
作者：
Déchanet, J;Merville, P;Moreau, JF
通讯作者：
Moreau, JF
影响因子：
15.3
作者：
DELIBERO, G;CASORATI, G;LANZAVECCHIA, A
通讯作者：
LANZAVECCHIA, A