Performance characteristics of new superficially porous particles.
Performance characteristics of new superficially porous particles.
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DOI：
10.1016/j.chroma.2012.08.036
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发表时间：
2012-10-05
期刊：
影响因子：
--
通讯作者：
Kirkland JJ
中科院分区：
文献类型：
--
作者：
Destefano JJ;Schuster SA;Lawhorn JM;Kirkland JJ
表面多孔颗粒（也称为熔核、核壳或多孔壳颗粒）在分离小分子方面比可比较的全多孔颗粒表现出明显的优势。由于具有优异的涡流分散特性（较小的范第姆特 A 项），熔核颗粒柱表现出非常高的效率。 2.7 μm Fused-Core 颗粒的色谱柱效率实际上可与亚 2 μm 全多孔颗粒的色谱柱相媲美，而背压仅为其一半左右。由于卓越的传质（动力学）特性（较小的范第姆特 C 项），这些熔核颗粒在较大分子中表现出特殊的优势，可以在高流动相速度下进行快速分离。该报告描述了不同粒径和多孔壳厚度对熔核颗粒色谱性能的影响。颗粒特性可以显着影响分离重要性的因素。例如，填充塔的塔板高度降低会受到粒径的影响。有趣的是，较大的熔核颗粒比较小的熔核颗粒显示出更小的降低的板高度。此外，多孔壳厚度对溶质保留和分离效率有很大影响，颗粒表面积对样品负载特性有直接影响。已开发出具有多种物理特性的熔核颗粒，可用于制备稳定、高效的填充柱。
Superficially porous particles (also called Fused-Core, core shell or porous shell particles) show distinct advantages over comparable totally porous particles for separating small molecules. Columns of Fused-Core particles exhibit very high efficiency because of superior eddy dispersion properties (smaller van Deemter A term). The efficiency for columns of 2.7 μm Fused-Core particles actually rivals that for sub-2 μm totally porous particles with only about one-half the back pressure. These Fused-Core particles show special advantages with larger molecules for fast separations at high mobile phase velocities because of superior mass transfer (kinetic) properties (smaller van Deemter C term). This report describes the effect of different particle size and porous shell thicknesses on chromatographic performance for Fused-Core particles. Particle characteristics can significantly affect factors of separation importance. For example, the reduced plate height of packed columns is affected by particle diameter. Interestingly, larger Fused-Core particles show smaller reduced plate heights than smaller Fused-Core particles. Also, porous shell thickness has a strong effect on solute retention as well as separation efficiency, and particle surface area has a direct influence on sample loading characteristics. Fused-Core particles with a wide range of physical characteristics have been developed that allows the preparation of stable, efficient packed columns.
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影响因子：
4.1
作者：
Gritti, Fabrice;Cavazzini, Alberto;Guiochon, Georges
通讯作者：
Guiochon, Georges
DOI：
10.1016/j.jpba.2009.05.011
发表时间：
2009-10-15
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
4.1
作者：
Gritti, Fabrice;Omamogho, Jesse;Guiochon, Georges
通讯作者：
Guiochon, Georges
影响因子：
4.1
作者：
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通讯作者：
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影响因子：
4.1
作者：
Wang, XL;Barber, WE;Carr, PW
通讯作者：
Carr, PW