Analgesic Effects of Tonic and Burst Dorsal Root Ganglion Stimulation in Rats With Painful Tibial Nerve Injury.
Analgesic Effects of Tonic and Burst Dorsal Root Ganglion Stimulation in Rats With Painful Tibial Nerve Injury.
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DOI：
10.1111/ner.13472
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发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
Pan B
中科院分区：
文献类型：
--
作者：
Yu G;Segel I;Tran H;Park HJ;Ross E;Hogan QH;Pan B
刺激背根神经节（DRG）是治疗慢性疼痛的有效方法。虽然爆发刺激已被证实能提高脊髓刺激的治疗效果，但目前临床上仅采用强直刺激波形进行DRG刺激。我们假设突发DRG刺激也可能在临床前神经性疼痛模型中产生镇痛作用。在临床前神经性疼痛模型中，我们评估了突发DRG刺激的治疗效果以及DRG刺激对DRG内炎症的可能影响。大鼠接受疼痛的胫骨神经损伤或假手术。DRG刺激的镇痛效果通过测试一系列诱发的疼痛相关行为以及使用条件位置偏好测量与自发性疼痛缓解相关的积极情感状态来评估。评估神经损伤或神经炎症的组织学证据。所有测试的波形（20hz -tonic， 20hz -burst和40hz -burst）在感觉测试和条件位置偏好中具有相似的镇痛作用。长期刺激DRG两周不改变神经损伤和神经炎症标志物的DRG表达。利用脉冲波形刺激DRG可能也适用于神经性疼痛的治疗。
Dorsal root ganglion (DRG) stimulation is effective in treating chronic pain. While burst stimulation has been proven to enhance the therapeutic efficacy in spinal cord stimulation, currently only a tonic stimulation waveform is clinically used in DRG stimulation. We hypothesized that burst DRG stimulation might also produce analgesic effect in a preclinical neuropathic pain model. We evaluated both the therapeutic effects of burst DRG stimulation and the possible effects of DRG stimulation upon inflammation within the DRG in a preclinical neuropathic pain model. Rats received either a painful tibial nerve injury or sham surgery. Analgesic effects of DRG stimulation were evaluated by testing a battery of evoked pain-related behaviors as well as measuring the positive affective state associated with relief of spontaneous pain using conditioned place preference. Histological evidence for neuronal trauma or neuroinflammation was evaluated. All of the waveforms tested (20 Hz-tonic, 20 Hz-burst, and 40 Hz-burst) have similar analgesic effects in sensory tests and conditioned place preference. Long-term DRG stimulation for two weeks does not change DRG expression of markers for nerve injury and neuroinflammation. DRG stimulation using burst waveform might be also suitable for treating neuropathic pain.
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影响因子：
2.8
作者：
Liem, Liong;Russo, Marc;Kramer, Jeffery
通讯作者：
Kramer, Jeffery
影响因子：
8.8
作者：
Yu G;Segel I;Zhang Z;Hogan QH;Pan B
通讯作者：
Pan B
影响因子：
4
作者：
Pan, Bin;Yu, Hongwei;Hogan, Quinn H.
通讯作者：
Hogan, Quinn H.
DOI：
10.1016/j.jpain.2009.07.011
发表时间：
2010-03
期刊：
The journal of pain
影响因子：
--
作者：
Wu HE;Gemes G;Zoga V;Kawano T;Hogan QH
通讯作者：
Hogan QH
影响因子：
7.4
作者：
Chao D;Zhang Z;Mecca CM;Hogan QH;Pan B
通讯作者：
Pan B