Learned avoidance from noxious mechanical simulation but not threshold semmes weinstein filament stimulation after nerve injury in rats.
Learned avoidance from noxious mechanical simulation but not threshold semmes weinstein filament stimulation after nerve injury in rats.
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DOI：
10.1016/j.jpain.2009.07.011
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Hogan QH
中科院分区：
文献类型：
--
作者：
Wu HE;Gemes G;Zoga V;Kawano T;Hogan QH
有害的机械刺激引起周围神经损伤后复杂和持续的痛觉过敏运动反应，这与对照动物在有害刺激或von Frey技术的阈点机械刺激后出现的短暂和简单的戒断形成鲜明对比。为了测试这些行为中哪一种表明疼痛，在坐骨神经结扎或单独切开皮肤的大鼠中，使用被动回避测试来确定与每种行为相关的体验的厌恶程度。18d后，每隔10min进行9次连续试验，测量降压潜伏期。在每次试验中，大鼠在下台后接受无刺激、针刺刺激或阈值Semmes Weinstein （SW）细丝刺激。反应要么是痛觉过敏反应，要么是短暂的反射性戒断。在SNL动物中，当动物表现出痛觉过敏反应时，针刺激产生了大量的习得性回避，但在SNL动物中只表现出简单的戒断反应，针刺激产生了最小的延长潜伏期。在SNL动物中使用阈值SW测试未发现习得性回避。这些发现表明，针刺刺激对大鼠的痛觉过敏反应是厌恶的。相比之下，脑电刺激和针刺激产生的仅仅是退缩，是最小的厌恶。
Noxious mechanical stimulation evokes a complex and sustained hyperalgesic motor response after peripheral nerve injury that contrasts with a brief and simple withdrawal that is seen after noxious stimulation in control animals or after threshold punctate mechanical stimulation by the von Frey technique. To test which of these behaviors indicate pain, the aversiveness of the experience associated with each was determined using a passive avoidance test in rats following sciatic nerve ligation or skin incision alone. After 18d, step-down latency was measured during 9 sequential trials at 10min intervals. At each trial, rats received either no stimulus, needle stimuli, or threshold Semmes Weinstein (SW) filament stimuli after stepping down. Reactions were either a hyperalgesic response or a brief reflexive withdrawal. In SNL animals, needle stimulation produced substantial learned avoidance when animals showed hyperalgesic responses, but produced minimal prolonged latency in SNL animals that showed only simple withdrawal responses. No learned avoidance developed using threshold SW testing in SNL animals. These findings show that needle stimulation is aversive in rats responding with hyperalgesic behavior. In contrast, SW stimulation, as well as needle stimulation that produced mere withdrawal, is minimally aversive.
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影响因子：
7.4
作者：
Rasmussen, PV;Sindrup, SH;Bach, FW
通讯作者：
Bach, FW
DOI：
10.1073/pnas.0901815106
发表时间：
2009-05-26
影响因子：
11.1
作者：
Kawano, Takashi;Zoga, Vasiliki;Sarantopoulos, Constantine
通讯作者：
Sarantopoulos, Constantine
影响因子：
7.4
作者：
Na, HS;Yoon, YW;Chung, JM
通讯作者：
Chung, JM
影响因子：
7.4
作者：
Nijsen, MJMA;Ongenae, NGH;Meulemans, AL
通讯作者：
Meulemans, AL
影响因子：
2
作者：
Kim, KJ;Yoon, YW;Chung, JM
通讯作者：
Chung, JM