The Triple Health Threat of Diabetes, Obesity, and Cancer-Epidemiology, Disparities, Mechanisms, and Interventions.
The Triple Health Threat of Diabetes, Obesity, and Cancer-Epidemiology, Disparities, Mechanisms, and Interventions.
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DOI：
10.1002/oby.23161
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Agurs-Collins T
中科院分区：
文献类型：
--
作者：
Brown JC;Carson TL;Thompson HJ;Agurs-Collins T
肥胖和2型糖尿病都是慢性、复发性、进行性疾病，被认为是多种类型癌症发展的危险因素。在最近的研讨会上，肥胖协会（TOS）在2019年肥胖周期间召集了“三重糖尿病，肥胖和癌症风险的新兴联系”，该领域的专家介绍了当前的科学并强调了现有的研究差距。专题包括：1）肥胖和糖尿病的流行病学及其与癌症风险的联系; 2）肥胖、糖尿病和癌症风险的种族和民族差异; 3）肥胖和糖尿病共同的生物学机制可能增加癌症风险; 4）可用于预防与肥胖和糖尿病相关的癌症发展的创新干预措施。本报告概述了研讨会，并介绍了关键的研究差距和迫切需要回答的问题，以推进该领域。肥胖、糖尿病和癌症的共同负担是世纪最大的公共卫生挑战之一。虽然研讨会的标题是“击中三重”，但人们认识到，能够打破肥胖、糖尿病和癌症之间的联系将是公共卫生和医学的“大满贯”。
Obesity and type 2 diabetes are both chronic, relapsing, progressive diseases that are recognized as risk factors for the development of multiple types of cancer. In a recent symposium “Hitting A Triple—Diabetes, Obesity, and the Emerging Links to Cancer Risk” convened by The Obesity Society (TOS) during ObesityWeek® 2019, experts in the field presented the current science and highlighted existing research gaps. Topics included: 1) the epidemiology of obesity and diabetes and their links to cancer risk; 2) racial and ethnic differences in obesity, diabetes, and cancer risk; 3) biological mechanisms common to obesity and diabetes that may increase cancer risk; and 4) innovative interventions that can be used to prevent the development of cancers related to obesity and diabetes. This report provides an overview of the symposium and describes key research gaps and pressing questions in need of answers to advance the field. The collective burden of obesity, diabetes, and cancer represents one of the largest public health challenges of the century. Although the symposium was titled “hitting a triple” it was recognized that being able to disrupt the linkages among obesity, diabetes, and cancer would be a “grand slam” for public health and medicine.
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影响因子：
13.6
作者：
Arnold M;Freisling H;Stolzenberg-Solomon R;Kee F;O'Doherty MG;Ordóñez-Mena JM;Wilsgaard T;May AM;Bueno-de-Mesquita HB;Tjønneland A;Orfanos P;Trichopoulou A;Boffetta P;Bray F;Jenab M;Soerjomataram I;CHANCES consortium
通讯作者：
CHANCES consortium
影响因子：
120.7
作者：
Cheng, Yiling J.;Kanaya, Alka M.;Imperatore, Giuseppina
通讯作者：
Imperatore, Giuseppina
DOI：
10.1056/nejmoa1309753
发表时间：
2014-01-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham SA;Kramer MR;Narayan KM
通讯作者：
Narayan KM
DOI：
10.1038/nrc1299
发表时间：
2004-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
8.8
作者：
Feng, Xiaoshuang;Song, Mingyang;Mucci, Lorelei A.
通讯作者：
Mucci, Lorelei A.