Malaria parasite development in the mosquito and infection of the mammalian host.
Malaria parasite development in the mosquito and infection of the mammalian host.
复制标题
DOI：
10.1146/annurev.micro.091208.073403
复制
发表时间：
2009
影响因子：
10.5
通讯作者：
Kappe SH
中科院分区：
文献类型：
--
作者：
Aly AS;Vaughan AM;Kappe SH
疟原虫子孢子是蚊子媒介中复杂发育过程的产物，注定会感染哺乳动物的肝脏。由于认识到蚊子阶段和红细胞前阶段是寄生虫生命周期的瓶颈，并且在这些阶段进行干预可以阻止传播并预防感染，因此引起了人们的关注。按蚊体内的寄生虫进展、子孢子通过蚊虫叮咬传播到哺乳动物宿主以及随后的肝脏感染的特征是侵入阶段的广泛迁移、细胞侵入和发育变化。哺乳动物宿主肝脏阶段的准备工作从蚊子开始，对子孢子进行广泛的重新编程，以支持有效的感染和生存。在这里，我们讨论了寄生虫发育进程的分子和细胞基础及其与蚊子和哺乳动物感染早期阶段宿主组织的相互作用。
Plasmodium sporozoites are the product of a complex developmental process in the mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to the mosquito stages and preerythrocytic stages owing to recognition that these are bottlenecks in the parasite life cycle and that intervention at these stages can block transmission and prevent infection. Parasite progression in the Anopheles mosquito, sporozoite transmission to the mammalian host by mosquito bite, and subsequent infection of the liver are characterized by extensive migration of invasive stages, cell invasion, and developmental changes. Preparation for the liver phase in the mammalian host begins in the mosquito with an extensive reprogramming of the sporozoite to support efficient infection and survival. Here, we discuss what is known about the molecular and cellular basis of the developmental progression of parasites and their interactions with host tissues in the mosquito and during the early phase of mammalian infection.
登录
查看更多内容
影响因子：
3.6
作者：
Aly, Ahmed S. I.;Mikolajczak, Sebastian A.;Rivera, Hilda Silva;Camargo, Nelly;Jacobs-Lorena, Vanessa;Labaied, Mehdi;Coppens, Isabelle;Kappe, Stefan H. I.
通讯作者：
Kappe, Stefan H. I.
影响因子：
14.9
作者：
Balaji S;Babu MM;Iyer LM;Aravind L
通讯作者：
Aravind L
影响因子：
4
作者：
Combe, Audrey;Moreira, Cristina;Menard, Robert
通讯作者：
Menard, Robert
影响因子：
64.5
作者：
CERAMI, C;FREVERT, U;NUSSENZWEIG, V
通讯作者：
NUSSENZWEIG, V
影响因子：
3.1
作者：
Dessens, JT;Mendoza, J;Sinden, RE
通讯作者：
Sinden, RE