Hydrogen Sulfide in the Adipose Tissue-Physiology, Pathology and a Target for Pharmacotherapy.
Hydrogen Sulfide in the Adipose Tissue-Physiology, Pathology and a Target for Pharmacotherapy.
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DOI：
10.3390/molecules22010063
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发表时间：
2016-12-31
期刊：
影响因子：
--
通讯作者：
Jamroz-Wiśniewska A
中科院分区：
文献类型：
--
作者：
Bełtowski J;Jamroz-Wiśniewska A
硫化氢（H2S）主要由胱硫醚γ-裂解酶（CSE）在脂肪组织中合成。几项研究表明，H2S参与脂肪形成，即前脂肪细胞向脂肪细胞的分化，最有可能是通过抑制磷酸二酯酶和增加环AMP浓度。硫化氢对脂肪组织胰岛素敏感性和葡萄糖摄取的影响存在争议。一些研究表明，H2S抑制胰岛素诱导的葡萄糖摄取，并且过量的H2S有助于代谢综合征中脂肪组织的胰岛素抵抗。相反，其他研究表明，H2S刺激葡萄糖摄取，其缺乏导致胰岛素抵抗。同样，硫化氢对脂肪组织脂解的影响也存在争议。血管周围脂肪组织产生的H2S通过激活平滑肌细胞中的ATP敏感性和/或电压门控钾通道来降低血管张力。高热量饮食诱导的实验性肥胖对血管周围脂肪组织中的H2S具有时间依赖性影响;短期和长期肥胖分别增加和减少H2S的产生。高脂血症一直被证明在各种脂肪组织库中抑制CSE-H2S途径。最后，H2S缺乏可能导致与肥胖/代谢综合征相关的脂肪组织炎症。
Hydrogen sulfide (H2S) is synthesized in the adipose tissue mainly by cystathionine γ-lyase (CSE). Several studies have demonstrated that H2S is involved in adipogenesis, that is the differentiation of preadipocytes to adipocytes, most likely by inhibiting phosphodiesterases and increasing cyclic AMP concentration. The effect of H2S on adipose tissue insulin sensitivity and glucose uptake is controversial. Some studies suggest that H2S inhibits insulin-induced glucose uptake and that excess of H2S contributes to adipose tissue insulin resistance in metabolic syndrome. In contrast, other studies have demonstrated that H2S stimulates glucose uptake and its deficiency contributes to insulin resistance. Similarly, the effect of H2S on adipose tissue lipolysis is controversial. H2S produced by perivascular adipose tissue decreases vascular tone by activating ATP-sensitive and/or voltage-gated potassium channels in smooth muscle cells. Experimental obesity induced by high calorie diet has a time dependent effect on H2S in perivascular adipose tissue; short and long-term obesity increase and decrease H2S production, respectively. Hyperglycemia has been consistently demonstrated to suppress CSE-H2S pathway in various adipose tissue depots. Finally, H2S deficiency may contribute to adipose tissue inflammation associated with obesity/metabolic syndrome.
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影响因子：
2.1
作者：
Beltowski, Jerzy;Guranowski, Andrzej;Halas, Krzysztof
通讯作者：
Halas, Krzysztof
DOI：
10.1152/ajpendo.00458.2014
发表时间：
2015-04-15
影响因子：
5.1
作者：
Choi, Eun-Kyung;Park, Hyun-Jung;Choi, Hye-Seon
通讯作者：
Choi, Hye-Seon
影响因子：
4.9
作者：
Fang, Liping;Zhao, Jing;Geng, Bin
通讯作者：
Geng, Bin
影响因子：
20.1
作者：
Fuster JJ;Ouchi N;Gokce N;Walsh K
通讯作者：
Walsh K
影响因子：
9.3
作者：
Beltowski, Jerzy;Guranowski, Andrzej;Wojtak, Andrzej
通讯作者：
Wojtak, Andrzej