Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine.
Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine.
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DOI：
10.1111/adb.12386
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发表时间：
2017-07
影响因子：
3.4
通讯作者：
Bossert JM
中科院分区：
文献类型：
--
作者：
Adhikary S;Caprioli D;Venniro M;Kallenberger P;Shaham Y;Bossert JM
在接受过自我给药甲基苯丙胺训练的大鼠中，戒断后（甲基苯丙胺渴望的孵化），在存在药物相关背景和离散线索的情况下，消退反应逐渐增加。这种潜伏期的条件反射因素尚不清楚。在这里，我们研究了不同的实验条件下的甲基苯丙胺渴望的孵化，以确定促成这种孵化的因素。我们还确定了大鼠对甲基苯丙胺引发的反应是否在戒断后潜伏。我们训练大鼠在不同的背景下（背景A）自我管理甲基苯丙胺14天（6小时/天）。杠杆按压与离散光提示配对。然后，我们在1天、1周或1个月后测试了背景A或不同的非药物背景（背景B）中的大鼠组在有或没有离散线索的情况下的消退反应。随后，我们测试了大鼠暴露于上下文，离散线索，或药物引发（0，0.25，和0.5毫克/公斤）诱导的药物寻求的恢复。在情境A或B中，戒断1周和1个月后的消退会话中的操作性反应高于1天后;这种效应是情境独立的。独立的戒断期，在灭绝会议的操作性反应较高时，响应导致特遣队交付的离散线索。消退后，离散线索诱导的恢复，但不是背景或药物引发诱导的恢复，逐步增加后退出。总之，孵化的甲基苯丙胺的渴望，在灭绝测试中评估，主要是介导的时间依赖性增加非增强操作性反应，这种效果是加强暴露离散的，但不是上下文，线索。
In rats trained to self-administer methamphetamine, extinction responding in the presence of drug-associated contextual and discrete cues progressively increases after withdrawal (incubation of methamphetamine craving). The conditioning factors underlying this incubation are unknown. Here, we studied incubation of methamphetamine craving under different experimental conditions to identify factors contributing to this incubation. We also determined whether the rats’ response to methamphetamine priming incubates after withdrawal. We trained rats to self-administer methamphetamine in a distinct context (context A) for 14 days (6-h/day). Lever presses were paired with a discrete light cue. We then tested groups of rats in context A or a different non-drug context (context B) after 1 day, 1 week, or 1 month for extinction responding with or without the discrete cue. Subsequently, we tested the rats for reinstatement of drug seeking induced by exposure to contextual, discrete cue, or drug priming (0, 0.25, and 0.5 mg/kg). Operant responding in the extinction sessions in contexts A or B was higher after 1 week and 1 month of withdrawal than after 1 day; this effect was context-independent. Independent of the withdrawal period, operant responding in the extinction sessions was higher when responding led to contingent delivery of the discrete cue. After extinction, discrete cue-induced reinstatement, but not context- or drug priming-induced reinstatement, progressively increased after withdrawal. Together, incubation of methamphetamine craving, as assessed in extinction tests, is primarily mediated by time-dependent increases in non-reinforced operant responding, and this effect is potentiated by exposure to discrete, but not contextual, cues.
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影响因子：
10.6
作者：
Caprioli D;Venniro M;Zeric T;Li X;Adhikary S;Madangopal R;Marchant NJ;Lucantonio F;Schoenbaum G;Bossert JM;Shaham Y
通讯作者：
Shaham Y
DOI：
10.1523/jneurosci.1914-12.2012
发表时间：
2012-08-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fanous S;Goldart EM;Theberge FR;Bossert JM;Shaham Y;Hope BT
通讯作者：
Hope BT
影响因子：
5.6
作者：
Bienkowski, P;Rogowski, A;Kostowski, W
通讯作者：
Kostowski, W
DOI：
10.1523/jneurosci.0005-12.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bossert JM;Stern AL;Theberge FR;Marchant NJ;Wang HL;Morales M;Shaham Y
通讯作者：
Shaham Y
影响因子：
3.4
作者：
Deroche-Gamonet, V;Martinez, A;Piazza, PV
通讯作者：
Piazza, PV