PEG hydrogels for the controlled release of biomolecules in regenerative medicine.
PEG hydrogels for the controlled release of biomolecules in regenerative medicine.
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DOI：
10.1007/s11095-008-9801-2
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发表时间：
2009-03
影响因子：
3.7
通讯作者：
Anseth KS
中科院分区：
文献类型：
--
作者：
Lin CC;Anseth KS
聚乙二醇（PEG）水凝胶广泛应用于各种生物医学应用，包括用于生物分子控释的基质和用于再生医学的支架。PEG水凝胶的设计、制造和表征依赖于对基本凝胶动力学的理解以及应用的目的。本文将重点介绍聚乙二醇基水凝胶的不同聚合机理，以及这些生物相容性水凝胶在再生医学中的应用。此外，还将讨论在保持生物分子的可用性和稳定性以及PEG水凝胶中生物分子的加载机制方面重要的设计标准。最后，我们对一些新兴的PEG水凝胶系统的新设计和应用进行了概述和展望，包括生物分子的时空控制递送、杂交水凝胶和用于受控干细胞分化的PEG水凝胶。
Polyethylene glycol (PEG) hydrogels are widely used in a variety of biomedical applications, including matrices for controlled release of biomolecules and scaffolds for regenerative medicine. The design, fabrication, and characterization of PEG hydrogels rely on the understanding of fundamental gelation kinetics as well as the purpose of the application. This review article will focus on different polymerization mechanisms of PEG-based hydrogels and the importance of these biocompatible hydrogels in regenerative medicine applications. Furthermore, the design criteria that are important in maintaining the availability and stability of the biomolecules as well as the mechanisms for loading of biomolecules within PEG hydrogels will also be discussed. Finally, we overview and provide a perspective on some of the emerging novel design and applications of PEG hydrogel systems, including the spatiotemporal-controlled delivery of biomolecules, hybrid hydrogels, and PEG hydrogels designed for controlled stem cell differentiation.
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影响因子：
29.4
作者：
Ehrick, Jason D.;Stokes, Sean;Daunert, Sylvia
通讯作者：
Daunert, Sylvia
影响因子：
10.8
作者：
Anseth, KS;Metters, AT;Bowman, CN
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Bowman, CN
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14
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通讯作者：
Prestwich, GD
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DuBose, JW;Cutshall, C;Metters, AT
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Metters, AT
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通讯作者：
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