Tooth number abnormality: from bench to bedside.
Tooth number abnormality: from bench to bedside.
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DOI：
10.1038/s41368-022-00208-x
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发表时间：
2023-01-06
影响因子：
14.9
通讯作者：
Sun, Yao
中科院分区：
文献类型：
--
作者：
Zhang, Han;Gong, Xuyan;Xu, Xiaoqiao;Wang, Xiaogang;Sun, Yao
牙数异常是最常见的牙发育性疾病之一，包括牙发育不全和多生牙。牙齿的发育受到许多发育信号的调节，如众所周知的Wnt、BMP、FGF、Shh和Eda通路，它们介导上皮和间充质之间持续的复杂相互作用。在这个过程中这些关键信号的异常表达最终可能会导致牙齿数量异常;然而，潜在的机制仍然难以捉摸。本文就牙齿发育的主要过程、牙齿数目异常发生机制的最新研究进展以及最新报道的牙齿数目异常的临床研究进行综述。此外，还讨论了基于发育生物学的牙齿数目异常的潜在治疗方法。本文不仅为临床牙数异常的诊断和治疗提供了参考，而且也为基础研究向临床应用的转化提供了便利。
Tooth number abnormality is one of the most common dental developmental diseases, which includes both tooth agenesis and supernumerary teeth. Tooth development is regulated by numerous developmental signals, such as the well-known Wnt, BMP, FGF, Shh and Eda pathways, which mediate the ongoing complex interactions between epithelium and mesenchyme. Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number; however, the underlying mechanisms remain elusive. In this review, we summarized the major process of tooth development, the latest progress of mechanism studies and newly reported clinical investigations of tooth number abnormality. In addition, potential treatment approaches for tooth number abnormality based on developmental biology are also discussed. This review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application.
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影响因子：
1.9
作者：
Chen, Ken-Chung;Huang, Vehn-Shyun;Huang, Tze-Ta
通讯作者：
Huang, Tze-Ta
影响因子：
3
作者：
Abdalla, Ebtesam M.;Mostowska, Adrianna;Ismail, Suzan R.
通讯作者：
Ismail, Suzan R.
影响因子：
3.7
作者：
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通讯作者：
Ye X
DOI：
10.1002/jez.b.21266
发表时间：
2009-06-15
影响因子：
2.2
作者：
Peterkova, Renata;Churava, Svatava;Lesot, Herve;Rothova, Michaela;Prochazka, Jan;Peterka, Miroslav;Klein, Ophir D.
通讯作者：
Klein, Ophir D.
影响因子：
2.7
作者：
Dasgupta K;Cesario JM;Ha S;Asam K;Deacon LJ;Song AH;Kim J;Cobb J;Yoon JK;Jeong J
通讯作者：
Jeong J