Age, gender, and racial differences in incidence and survival in primary CNS lymphoma.
Age, gender, and racial differences in incidence and survival in primary CNS lymphoma.
复制标题
DOI：
10.1038/bjc.2011.357
复制
发表时间：
2011-10-25
影响因子：
8.8
通讯作者：
McCarthy, B. J.
中科院分区：
文献类型：
--
作者：
Villano, J. L.;Koshy, M.;Shaikh, H.;Dolecek, T. A.;McCarthy, B. J.
原发性中枢神经系统淋巴瘤（PCNSL）是一种罕见的淋巴结非霍奇金淋巴瘤亚型，占新诊断的中枢神经系统（CNS）肿瘤的14%。本研究的目的是分析这些罕见肿瘤的流行病学、发病率和结局。原发性脑和CNS淋巴瘤病例是从1980-2008年的监测、流行病学和最终结果（SEER）研究数据集中确定的，用于分析发病率和生存率的趋势。使用SEER*Stat v. 7.0.4软件分析数据。PCNSL的总发病率为0.47/10万人-年。男性的发病率显著高于女性，诊断时0-49岁的黑人显著高于白人，诊断时50岁及以上的白人显著高于黑人。在1995年至1999年发病率显著下降后，发病率略有上升;诊断时年龄在75岁以上的人群发病率随时间的推移增加最显著。诊断时年龄在0-49岁的白人的5年生存率显著高于黑人，但主要是由0-49岁的白色女性驱动的。老年人PCNSL发病率增加，老年黑人发病率低于白色人群。存活率仍然很低，并受到与艾滋病毒感染和高龄有关的因素的不利影响。
Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin lymphoma that accounts for ∼4% of newly diagnosed central nervous system (CNS) tumours. The objective of this study was to analyse the epidemiology, incidence, and outcome of these rare tumours. Primary brain and CNS lymphoma cases were identified from the Surveillance, Epidemiology, and End Results (SEER) research data sets for the years 1980–2008 for analysis of trends in incidence and survival. SEER*Stat v. 7.0.4 software was used to analyse the data. The overall incidence rate of PCNSL was 0.47 per 100 000 person-years. The incidence was significantly higher in males compared with females, blacks aged 0–49 years at diagnosis compared with whites, and whites aged 50 years and older at diagnosis compared with blacks. After a significant decline in incidence between 1995 and 1999, incidence rates rose slightly; those aged 75+ years at diagnosis had the most dramatic increase in incidence rates over time. Five-year survival rates were significantly higher in whites compared with blacks aged 0–49 years at diagnosis, but was primarily driven by white women aged 0–49 years. There is an increase in incidence of PCNSL in the elderly, and elderly blacks have lower incidence compared with white population. Survival remains poor and is negatively dominated by factors associated with HIV infection and advanced age.
登录
查看更多内容
影响因子：
6.2
作者：
Olson, JE;Janney, CA;O'Neill, BP
通讯作者：
O'Neill, BP
影响因子：
1.9
作者：
BROWN, CC
通讯作者：
BROWN, CC
影响因子：
11.4
作者：
Montesinos-Rongen, M.;Brunn, A.;Deckert, M.
通讯作者：
Deckert, M.
DOI：
10.1093/jnci/88.10.675
发表时间：
1996-05-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Cote, TR;Manns, A;Parkin, W
通讯作者：
Parkin, W
影响因子：
51.1
作者：
Thiel, Eckhard;Korfel, Agnieszka;Weller, Michael
通讯作者：
Weller, Michael