The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review.
The Use of Hydrogels for the Treatment of Bone Osteosarcoma via Localized Drug-Delivery and Tissue Regeneration: A Narrative Review.
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DOI：
10.3390/gels9040274
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发表时间：
2023-03-25
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--
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骨肉瘤是一种恶性骨肿瘤，导致低死亡率和发病率。通过传统方法管理这种癌症涉及侵入性治疗选择，使患者面临增加的不良事件风险。使用水凝胶靶向骨肉瘤在体外和体内都显示出有希望的结果，以根除肿瘤细胞，同时促进骨再生。水凝胶负载化疗药物为骨肉瘤的位点特异性靶向治疗提供了一条途径。目前的研究表明，当暴露于掺杂的水凝胶支架时，体内肿瘤消退和体外肿瘤细胞溶解。此外，新型刺激响应性水凝胶能够与组织微环境反应以促进抗肿瘤药物的受控释放，并且具有可以调节的生物力学性质。本文对目前的文献进行了叙述性综述，讨论了用于治疗骨肉瘤的不同水凝胶（包括刺激响应性水凝胶）的体外和体内研究。未来的应用，以解决这种骨癌的患者治疗进行了讨论。
Osteosarcoma is a malignant tumor of bone that leads to poor mortality and morbidity. Management of this cancer through conventional methods involves invasive treatment options that place patients at an increased risk of adverse events. The use of hydrogels to target osteosarcoma has shown promising results both in vitro and in vivo to eradicate tumor cells while promoting bone regeneration. The loading of hydrogels with chemotherapeutic drugs provides a route for site-specific targeted therapy for osteosarcoma. Current studies demonstrate tumor regression in vivo and lysis of tumor cells in vitro when exposed to doped hydrogel scaffolds. Additionally, novel stimuli-responsive hydrogels are able to react with the tissue microenvironment to facilitate the controlled release of anti-tumor drugs and with biomechanical properties that can be modulated. This narrative review of the current literature discusses both in vitro and in vivo studies of different hydrogels, including stimuli-responsive, designed to treat bone osteosarcoma. Future applications to address patient treatment for this bone cancer are also discussed.
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影响因子：
81.5
作者：
Beird, Hannah C.;Bielack, Stefan S.;Gorlick, Richard
通讯作者：
Gorlick, Richard
DOI：
10.3181/0808-mr-250
发表时间：
2009-02
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Blanco E;Kessinger CW;Sumer BD;Gao J
通讯作者：
Gao J
DOI：
10.3390/bios11020055
发表时间：
2021-02-20
期刊：
Biosensors
影响因子：
--
作者：
Barani M;Mukhtar M;Rahdar A;Sargazi S;Pandey S;Kang M
通讯作者：
Kang M
影响因子：
4.2
作者：
Ayerza, Miguel A.;Farfalli, German L.;Luis Muscolo, D.
通讯作者：
Luis Muscolo, D.
影响因子：
6
作者：
Choi, Jinhyang;Curtis, Stephen J.;Nikitin, Alexander Yu.
通讯作者：
Nikitin, Alexander Yu.