Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior.
Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior.
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DOI：
10.1016/j.bbr.2014.04.029
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发表时间：
2014-08-01
影响因子：
2.7
通讯作者：
Savage, Daniel D.
中科院分区：
文献类型：
--
作者：
Hamilton, Derek A.;Barto, Daniel;Rodriguez, Carlos I.;Magcalas, Christy M.;Fink, Brandi C.;Rice, James P.;Bird, Clark W.;Davies, Suzy;Savage, Daniel D.
关键词：
持续的社会行为缺陷是与产前发育期间暴露于乙醇相关的主要负面后果之一。我们实验室之前的工作已经将大鼠适度产前酒精暴露（PAE）后的社会行为缺陷与腹外侧额叶皮层的功能改变联系起来。除了社会行为外，由腹外侧额叶皮层组成的区域对于从口面部运动到面对变化后果时灵活改变行为的各种过程都是至关重要的。然而，中度PAE后腹外侧额叶皮质功能改变的更广泛的行为影响尚未得到研究。在本研究中，我们评估了中度PAE对社会行为、舌头伸出和灵活性的影响，这需要修改一个完善的空间反应。PAE大鼠表现出舌头突出、空间柔韧性降低、摔跤增加和调查减少的缺陷，表明中度PAE后与腹外侧额叶皮质功能相关的一些行为受损。线性判别分析显示，角力和舌突是PAE大鼠与糖精暴露对照大鼠的最佳判别指标。我们还评估了年轻成年大鼠（4-5个月）或老年大鼠（10-11个月）的所有行为，以解决成年后行为缺陷的持久性以及早期乙醇暴露与老年之间可能的相互作用。每个领域的行为缺陷持续到成年（10-11岁），然而，没有证据表明年龄在研究的年龄范围内增强了中度PAE的影响。
Persistent deficits in social behavior are among the major negative consequences associated with exposure to ethanol during prenatal development. Prior work from our laboratory has linked deficits in social behavior following moderate prenatal alcohol exposure (PAE) in the rat to functional alterations in the ventrolateral frontal cortex. In addition to social behaviors, the regions comprising the ventrolateral frontal cortex are critical for diverse processes ranging from orofacial motor movements to flexible alteration of behavior in the face of changing consequences. The broader behavioral implications of altered ventrolateral frontal cortex function following moderate PAE have, however, not been examined. In the present study we evaluated the consequences of moderate PAE on social behavior, tongue protrusion, and flexibility in a variant of the Morris water task that required modification of a well-established spatial response. PAE rats displayed deficits in tongue protrusion, reduced flexibility in the spatial domain, increased wrestling, and decreased investigation, indicating that several behaviors associated with ventrolateral frontal cortex function are impaired following moderate PAE. A linear discriminant analysis revealed that measures of wrestling and tongue protrusion provided the best discrimination of PAE rats from saccharin-exposed control rats. We also evaluated all behaviors in young adult (4-5 mos.) or older (10-11 mos.) rats to address the persistence of behavioral deficits in adulthood and possible interactions between early ethanol exposure and advancing age. Behavioral deficits in each domain persisted well into adulthood (10-11 mos.), however, there was no evidence that age enhances the effects of moderate PAE within the age ranges that were studied.
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影响因子：
2.7
作者：
Hamilton, Derek A.;Candelaria-Cook, Felicha T.;Akers, Katherine G.;Rice, James P.;Maes, Levi I.;Rosenberg, Martina;Valenzuela, C. Fernando;Savage, Daniel D.
通讯作者：
Savage, Daniel D.
影响因子：
14.5
作者：
Berthoz, S.;Armony, J. L.;Dolan, R. J.
通讯作者：
Dolan, R. J.
DOI：
10.1002/ajmg.1320560213
发表时间：
1995-03-27
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
BUNTINX, IM;HENNEKAM, RCM;FRYNS, JP
通讯作者：
FRYNS, JP
影响因子：
3.2
作者：
Hamilton, Derek A.
通讯作者：
Hamilton, Derek A.
影响因子：
2.9
作者：
KELLY, SJ;DILLINGHAM, RR
通讯作者：
DILLINGHAM, RR