Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development.
Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development.
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DOI：
10.1016/j.bbr.2010.05.048
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发表时间：
2010-12-06
影响因子：
2.7
通讯作者：
Savage, Daniel D.
中科院分区：
文献类型：
--
作者：
Hamilton, Derek A.;Candelaria-Cook, Felicha T.;Akers, Katherine G.;Rice, James P.;Maes, Levi I.;Rosenberg, Martina;Valenzuela, C. Fernando;Savage, Daniel D.
我们实验室最近的研究结果表明，额叶皮质功能，结构可塑性和相关的社会行为的改变是产前大脑发育过程中暴露于中等水平乙醇的持久后果。与胎儿乙醇相关的立即早期基因（IEG）c-fos和Arc表达的减少以及额叶皮质腹外侧和内侧方面树枝棘密度的改变表明了一种分离，让人想起Kolb等人所描述的情况，其中这些方面额叶皮质经历相互的经验依赖性变化。除了提供一个简短的回顾胎儿乙醇暴露大鼠的社会行为和额叶皮质功能的可用数据，本文提出了新的数据，社会经验相关的IEG表达在额叶皮质的四个区域（Zilles LO，VLO，Fr 1，Fr 2），我们以前的数据一起评估从AID和Cg 3。在正常大鼠的社会经验有关的一个独特的模式IEG的表达在额叶皮层的腹外侧和内侧方面，一般更大的表达观察到在腹外侧额叶皮层。相比之下，较弱的表达，观察到在所有方面的额叶皮质乙醇暴露的大鼠，与经验相关的增加内侧无颗粒皮质除外。社会调查和摔跤/拳击相关的行为差异与活动相关的IEG的表达模式在糖精和乙醇暴露的大鼠进行调查的地区。这些观察结果表明，招聘和表达的IEGs在额叶皮层以下的社会经验是潜在的重要了解的长期后果，中度产前乙醇暴露对额叶皮层功能，突触可塑性和相关行为。
Recent findings from our laboratory indicate that alterations in frontal cortex function, structural plasticity, and related social behaviors are persistent consequences of exposure to moderate levels of ethanol during prenatal brain development. Fetal-ethanol-related reductions in the expression of the immediate early genes (IEGs) c-fos and Arc and alterations in dendritic spine density in ventrolateral and medial aspects of frontal cortex suggest a dissociation reminiscent of that described by Kolb et al. in which these aspects of frontal cortex undergo reciprocal experience-dependent changes. In addition to providing a brief review of the available data on social behavior and frontal cortex function in fetal-ethanol-exposed rats, the present paper presents novel data on social-experience-related IEG expression in four regions of frontal cortex (Zilles LO, VLO, Fr1, Fr2) that are evaluated alongside our prior data from AID and Cg3. Social experience in normal rats was related to a distinct pattern of IEG expression in ventrolateral and medial aspects of frontal cortex, with generally greater expression observed in ventrolateral frontal cortex. In contrast, weaker expression was observed in all aspects of frontal cortex in ethanol-exposed rats, with the exception of an experience-related increase in the medial agranular cortex. Behaviors related to social investigation and wrestling/boxing were differentially correlated with patterns of activity-related IEG expression in the regions under investigation for saccharin- and ethanol-exposed rats. These observations suggest that recruitment and expression of IEGs in frontal cortex following social experience are potentially important for understanding the long-term consequences of moderate prenatal ethanol exposure on frontal cortex function, synaptic plasticity, and related behaviors.
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影响因子：
14.5
作者：
Berthoz, S.;Armony, J. L.;Dolan, R. J.
通讯作者：
Dolan, R. J.
影响因子：
2.9
作者：
ABEL, EL
通讯作者：
ABEL, EL
影响因子：
2.3
作者：
Hamilton, Gillian F.;Whitcher, Lee T.;Klintsova, Anna Y.
通讯作者：
Klintsova, Anna Y.
影响因子：
3.7
作者：
Crombag, HS;Gorny, G;Robinson, TE
通讯作者：
Robinson, TE
DOI：
10.1111/j.1530-0277.1990.tb01222.x
发表时间：
1990-10-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
CONRY, J
通讯作者：
CONRY, J