Gender differences in the prognostic value of exercise treadmill test characteristics.
Gender differences in the prognostic value of exercise treadmill test characteristics.
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DOI：
10.1016/j.ahj.2011.01.021
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发表时间：
2011-05
影响因子：
4.8
通讯作者：
Masoudi, Frederick A.
中科院分区：
文献类型：
--
作者：
Daugherty, Stacie L.;Magid, David J.;Kikla, Jennifer R.;Hokanson, John E.;Baxter, Judith;Ross, Colleen A.;Masoudi, Frederick A.
虽然运动平板试验（ETT）是已知的敏感性和特异性较低的女性冠心病的诊断，很少有人知道性别差异的ETT变量的预后重要性。我们研究了2001年7月至2004年6月期间在社区系统中接受ETT的9569例连续患者（46.8%为女性）。我们评估了ETT变量（运动能力、症状、ST段偏移、心率恢复和变时性反应）与调整患者和负荷试验特征后的全因死亡和心肌梗死时间之间的相关性。模型按性别分层，以确定ETT变量和结局之间的关系。在整个人群中，运动能力和心率恢复与全因死亡显著相关，而运动能力、胸痛和ST段偏移与随后的MI显著相关。ETT变量和结果之间的关系在男性和女性之间相似，除了运动能力异常，这与男性的死亡有显著更强的相关性（男性：HR = 2.89，95% CI 1.89-4.44;女性：HR = 0.99，95% CI 0.52-1.93;交互作用<p=0.01）;和变时性功能不全，这与女性MI的关系显著更强（男性：HR = 1.29，95% CI 0.74-2.20;女性：HR= 2.79，95% CI 0.94-8.27;交互作用p =0.04）。虽然许多传统的ETT变量在男性和女性中具有相似的预后价值，但运动能力在男性中更重要，而变时性功能不全在女性中更重要。未来的研究应该在其他人群中证实这些发现。
Although exercise treadmill testing (ETT) is known to be less sensitive and specific for diagnosis of coronary disease in women, little is known about gender differences in the prognostic importance of ETT variables. We studied9569 consecutive patients (46.8% women) referred for ETT between July 2001- June 2004 in a community-based system. We assessed the association between ETT variables (exercise capacity, symptoms, ST-segment deviations, heart rate recovery, and chronotropic response) and time to all-cause death and myocardial infarction adjusting for patient and stress test characteristics. Models were stratified by gender to determine the relationship between ETT variables and outcomes. In the entire population, exercise capacity and heart rate recovery were significantly associated with all-cause death, whereas, exercise capacity, chest pain and ST-segment deviations were significantly associated with subsequent MI. The relationship between ETT variables and outcomes were similar between men and women except for abnormal exercise capacity, which was had a significantly stronger association with death in men (men: HR = 2.89, 95% CI 1.89–4.44; women: HR = 0.99, 95% CI 0.52–1.93; interaction <p=0.01); and chronotropic incompetence, which had a significantly stronger relationship with MI in women (men: HR = 1.29, 95% CI 0.74–2.20; women: HR= 2.79, 95% CI 0.94–8.27; interaction p =0.04). While many traditional ETT variables had similar prognostic value in both men and women, exercise capacity was more prognostically important in men and chronotropic incompetence was more important in women. Future studies should confirm these findings in additional populations.
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影响因子：
2.8
作者：
Khan, MN;Pothier, CE;Lauer, MS
通讯作者：
Lauer, MS
DOI：
10.1016/0735-1097(93)90832-l
发表时间：
1993-07-01
影响因子：
24
作者：
MORRIS, CK;MYERS, J;HIDEG, A
通讯作者：
HIDEG, A
运动测试预测无症状妇女心血管疾病和全因死亡的能力--血脂研究诊所流行病研究 20 年的跟踪调查
影响因子：
120.7
作者：
Mora, S;Redberg, RF;Blumenthal, RS
通讯作者：
Blumenthal, RS
影响因子：
158.5
作者：
MARK, DB;SHAW, L;PRYOR, DB
通讯作者：
PRYOR, DB
影响因子：
2.8
作者：
Morshedi-Meibodi, A;Larson, MG;Vasan, RS
通讯作者：
Vasan, RS