Nanomagnetic-mediated drug delivery for the treatment of dental disease.
Nanomagnetic-mediated drug delivery for the treatment of dental disease.
复制标题
DOI：
10.1016/j.nano.2018.01.013
复制
发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Masri R
中科院分区：
文献类型：
--
作者：
Ji Y;Choi SK;Sultan AS;Chuncai K;Lin X;Dashtimoghadam E;Melo MA;Weir M;Xu H;Tayebi L;Nie Z;Depireux DA;Masri R
保持牙髓的活力，高度神经支配和高度血管化，牙齿的最内层，是任何牙科手术的关键目标。在受伤后，用特定疗法靶向牙髓是具有挑战性的，因为它被包裹在硬组织中。该项目描述了一种可以有效地将治疗剂递送到牙髓的方法。这种方法依赖于纳米颗粒的使用，纳米颗粒可以通过磁力主动引导到牙髓，穿过牙本质（牙齿的中间层）中天然存在的通道。这种方法可以减轻损伤牙髓的炎症反应，促进牙科粘合剂向牙本质的渗透。这样的递送方法将比现有的可用于治疗受伤牙髓的治疗选择更便宜，并且更少疼痛和更少创伤。这项技术将是简单的，可以很容易地转化为临床使用。在这篇手稿中，描述了将载药纳米颗粒引导和递送到牙髓的技术。这项技术利用了从牙本质延伸到牙髓的天然牙本质小管，以及磁力来主动引导铁纳米颗粒深入牙齿结构。这项技术在大鼠磨牙和新鲜拔出的人类牙齿上进行了测试，可用于将载药纳米颗粒输送到牙髓，或增强市售树脂粘合剂与牙本质的粘合强度。
Maintaining the vitality of the dental pulp, the highly innervated and highly vascular, innermost layer of the tooth, is a critical goal of any dental procedure. Upon injury, targeting the pulp with specific therapies is challenging because it is encased in hard tissues. This project describes a method that can effectively deliver therapeutic agents to the pulp. This method relies on the use of nanoparticles that can be actively steered using magnetic forces to the pulp, traveling through naturally occurring channels in the dentin (the middle layer of the tooth). This method can reduce the inflammation of injured pulp and improve the penetration of dental adhesives into dentin. Such a delivery method would be less expensive, and both less painful and less traumatic than existing therapeutic options available for treatment of injured dental pulp. This technique would be simple and could be readily translated to clinical use. In this manuscript, technology to steer and deliver drug-laden nanoparticles to the tooth pulp is described. This technology exploits naturally occurring dentinal tubules that extend from the dentin to the pulp, and magnetic forces to actively steer iron nanoparticles deep into the tooth structure. This technology was tested on rat molar teeth and in freshly extracted human teeth and can be used to deliver drug-laden nanoparticles to the pulp, or to enhance the bond strength of commercially available resin adhesives to the tooth dentin.
登录
查看更多内容
影响因子：
9.7
作者：
Kim, Young Kyung;Mai, Sui;Mazzoni, Annalisa;Liu, Yan;Tezvergil-Mutluay, Arzu;Takahashi, Kei;Zhang, Kai;Pashley, David H.;Tay, Franklin R.
通讯作者：
Tay, Franklin R.
影响因子：
4.9
作者：
Jain, Tapan K.;Reddy, Maram K.;Labhasetwar, Vinod
通讯作者：
Labhasetwar, Vinod
影响因子：
2.2
作者：
Lübbe, AS;Alexiou, C;Bergemann, C
通讯作者：
Bergemann, C
影响因子：
9.7
作者：
Lohbauer, Ulrich;Wagner, Andrea;Mueller, Frank A.
通讯作者：
Mueller, Frank A.
影响因子：
2.7
作者：
COLLARES, Fabricio Mezzomo;KLEIN, Mariana;SAMUEL, Susana Maria Werner
通讯作者：
SAMUEL, Susana Maria Werner