Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid.
Determination and metabolism of dithiol chelating agents. VIII. Metal complexes of meso-dimercaptosuccinic acid.
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二硫醇螯合剂的测定和代谢。
DOI：
10.1016/0041-008x(89)90094-x
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发表时间：
1989
影响因子：
3.8
通讯作者：
Fernando,Q
中科院分区：
文献类型：
--
作者：
Rivera,M;Zheng,W;Aposhian,HV;Fernando,Q
用电位法和红外光谱法研究了meso-二巯基丁二酸（DMSA）与Pb ~（2+）、Cd ~（2+）、Hg ~（2+）的配合物。发现该二巯基金属结合剂形成络合物，其结构取决于待络合的金属离子。在Pb 2+和Cd 2+的情况下，一个氧原子和一个硫原子作为施主原子;在Hg 2+的情况下，两个硫原子作为施主原子。所有金属螯合物的溶解度被发现是pH依赖性的。镉和铅的络合物在pH 1.0至7.1范围内不溶，但当非配位的巯基和羧酸基团被离子化时溶解。汞络合物在pH 1.0至3.0范围内不溶。当其中一个非配位的羧酸基团被电离时，它溶解。合成了meso-DMSA的二甲酯（DiMe-meso-DMSA），测定了其酸离解常数（pK 1 = 6.38，pK 2 = 8.00）。酯化反应改变了meso-DMSA的配位性质，使其两个硫原子与Hg ~（2+）、Cd ~（2+）或Pb ~（2+）配位。内消旋-DMSA的酯化也改变其生物学性质。DiMe-meso-DMSA，当给予大鼠镉给药后3天，大大增加了镉通过胆汁的排泄。相比之下，内消旋-DMSA缺乏这种活性。
Metal complexes of meso-dimercaptosuccinic acid (DMSA) with Pb2+, Cd2+, and Hg2+were studied by potentiometric and infrared methods. This dimercapto metal-binding agent was found to form complexes whose structures are dependent on the metal ion to be complexed. In the cases of Pb2+and Cd2+, one oxygen and one sulfur act as the donor atoms; in the case of Hg2+, two sulfur atoms act as the donors. The solubilities of all metal chelates were found to be pH dependent. Complexes of cadmium and lead are insoluble in the pH range 1.0 to 7.1, but are solubilized when the noncoordinated sulfhydryl and carboxylic acid groups are ionized. The mercury complex is insoluble in the pH range 1.0 to 3.0. It dissolves when one of the noncoordinated carboxylic acid groups is ionized. The dimethyl ester of meso-DMSA (DiMe-meso-DMSA) was synthesized and its acid dissociation constants were determined (pK1= 6.38 and pK2= 8.00). Esterification of the carboxyl groups of meso-DMSA changes its coordination properties in that the two sulfur atoms of DiMe-meso-DMSA are used to coordinate with Hg2+, Cd2+, or Pb2+. Esterification of meso-DMSA also changes its biological properties. DiMe-meso-DMSA, when given to rats 3 days after Cd administration, greatly increased the excretion of Cd via bile. In contrast, meso-DMSA was devoid of such activity.
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二硫醇螯合剂的测定和代谢：尿液中氧化二硫醇的电解和化学还原。
影响因子：
2.9
作者：
Maiorino,RM;Barry,TJ;Aposhian,HV
通讯作者：
Aposhian,HV
胱氨酸尿症患者使用乙酰半胱氨酸的经验。
DOI：
10.1016/s0022-5347(17)66955-6
发表时间：
1975
期刊：
The Journal of urology
影响因子：
--
作者：
W. Mulvaney;T. quilter;A. Mortera
通讯作者：
A. Mortera
巯基丁二酸和 α,α-二巯基丁二酸的金属螯合物
DOI：
--
发表时间：
1965
期刊：
影响因子：
--
作者：
G. R. Lenz;A. Martell
通讯作者：
A. Martell
胱氨酸和 N-2-巯基乙基-1, 3-二氨基丙烷之间的硫醇-二硫化物交换作为胱氨酸尿症的潜在治疗方法。
影响因子：
2.9
作者：
P. Blackburn;C. Peterson
通讯作者：
C. Peterson
影响因子：
5.8
作者：
Maiorino,RM;Aposhian,HV
通讯作者：
Aposhian,HV