Optimized flow compensation for contrast-enhanced T1-weighted Wave-CAIPI 3D MPRAGE imaging of the brain.
Optimized flow compensation for contrast-enhanced T1-weighted Wave-CAIPI 3D MPRAGE imaging of the brain.
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DOI：
10.1186/s41747-023-00351-y
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发表时间：
2023-07-03
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
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在平行成像（CAIPI）磁化制备的快速梯度回波（MPRAGE）成像中，在高加速t1加权对比增强波控混叠中观察到与血流相关的伪影，并可能导致诊断的不确定性。我们开发了一种优化的流量缓解Wave-CAIPI MPRAGE采集协议，通过在定制的流量模拟中进行测试来减少这些工件。在幻影实验中，结合流量补偿梯度和径向重序k空间采集，最大限度地减少了流量伪影，并将其纳入优化序列。在64例成人患者中对优化的MPRAGE序列进行了临床评估，这些患者均接受了无流量补偿和优化流量补偿参数的对比增强Wave-CAIPI MPRAGE成像。所有图像均以3点李克特量表评估血流相关伪影、信噪比（SNR）、灰质对比度、增强病变对比度和图像清晰度的存在。在64个案例中，对于等级1和等级2，优化后的流量缓解协议分别减少了89%和94%的与流量相关的工件。所有受试者的信噪比、灰质对比度、增强病变对比度和图像清晰度被评为标准和血流缓解波- caipi MPRAGE相同。优化后的流量缓解协议在大多数情况下成功地减少了与流量相关的工件的存在。随着使用新型编码方案的加速MRI在临床实践中越来越多地采用，我们的工作强调需要认识和制定策略，以最大限度地减少意外伪影的存在和图像质量的降低，这是实现短扫描时间的潜在妥协。•流量缓解技术使与流量相关的工件减少了89-94%。•图像质量、信噪比、增强病变显著性和图像清晰度通过流缓解技术得以保留。•缓解流量减少了与流量相关的伪影模拟增强病变的情况下的诊断不确定性。
Flow-related artifacts have been observed in highly accelerated T1-weighted contrast-enhanced wave-controlled aliasing in parallel imaging (CAIPI) magnetization-prepared rapid gradient-echo (MPRAGE) imaging and can lead to diagnostic uncertainty. We developed an optimized flow-mitigated Wave-CAIPI MPRAGE acquisition protocol to reduce these artifacts through testing in a custom-built flow phantom. In the phantom experiment, maximal flow artifact reduction was achieved with the combination of flow compensation gradients and radial reordered k-space acquisition and was included in the optimized sequence. Clinical evaluation of the optimized MPRAGE sequence was performed in 64 adult patients, who all underwent contrast-enhanced Wave-CAIPI MPRAGE imaging without flow-compensation and with optimized flow-compensation parameters. All images were evaluated for the presence of flow-related artifacts, signal-to-noise ratio (SNR), gray-white matter contrast, enhancing lesion contrast, and image sharpness on a 3-point Likert scale. In the 64 cases, the optimized flow mitigation protocol reduced flow-related artifacts in 89% and 94% of the cases for raters 1 and 2, respectively. SNR, gray-white matter contrast, enhancing lesion contrast, and image sharpness were rated as equivalent for standard and flow-mitigated Wave-CAIPI MPRAGE in all subjects. The optimized flow mitigation protocol successfully reduced the presence of flow-related artifacts in the majority of cases. Relevance statement As accelerated MRI using novel encoding schemes become increasingly adopted in clinical practice, our work highlights the need to recognize and develop strategies to minimize the presence of unexpected artifacts and reduction in image quality as potential compromises to achieving short scan times. Key points • Flow-mitigation technique led to an 89–94% decrease in flow-related artifacts. • Image quality, signal-to-noise ratio, enhancing lesion conspicuity, and image sharpness were preserved with the flow mitigation technique. • Flow mitigation reduced diagnostic uncertainty in cases where flow-related artifacts mimicked enhancing lesions.
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影响因子：
3.5
作者：
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通讯作者：
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