Fractal rigidity by enhanced sympatho-vagal antagonism in heartbeat interval dynamics elicited by central application of corticotropin-releasing factor in mice
Fractal rigidity by enhanced sympatho-vagal antagonism in heartbeat interval dynamics elicited by central application of corticotropin-releasing factor in mice
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小鼠中枢应用促肾上腺皮质激素释放因子引起的心跳间隔动态中交感迷走神经拮抗作用增强导致的分形刚性
DOI：
10.1007/s00285-006-0375-5
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发表时间：
2006
影响因子：
1.9
通讯作者：
Oliver Stiedl
中科院分区：
文献类型：
--
作者：
Michael Meyer;Oliver Stiedl
在清醒的无拘束小鼠中研究了侧脑室应用神经肽促肾上腺皮质激素释放因子（CRF）后心跳间期波动的动力学。采用非线性信号处理中的非参数技术：延迟向量方差（DVV）分析、高阶变异性（HOV）分析、经验模态分解（EMD）、多尺度嵌入空间分解（MESD）、多指数多重分形（MEMF）分析等，对遥测心电监测的心脏时间序列进行分析。分析支持的猜想，正常对照小鼠的心脏动力学的确定性和随机元素，是非平稳的，非线性的，并发挥多重分形特性。中央应用CRF导致心动过缓和心跳波动的变异性增加。由CRF引起的动力学性质的改变反映了心脏控制的内在结构复杂性的显著丧失，这是由于中枢神经自主神经过度兴奋，即，增强交感迷走神经拮抗作用。动态复杂性的变化的特点是被称为分形刚度的效果，导致在波动的环境中的外部挑战的适应性显着受损。动力性神经心脏病的影响，作为一个主要的沉淀因素的倾向心律失常或心脏性猝死的未经检查的中央CRF释放在重大的急性生活事件的人进行了严格的讨论。
The dynamics of heartbeat interval fluctuations were studied in awake unrestrained mice following intracerebroventricular application of the neuropeptide corticotropin-releasing factor (CRF). The cardiac time series derived from telemetric ECG monitoring were analyzed by non-parametric techniques of nonlinear signal processing: delay-vector variance (DVV) analysis, higher-order variability (HOV) analysis, empirical mode decomposition (EMD), multiscale embedding-space decomposition (MESD), multiexponent multifractal (MEMF) analysis. The analyses support the conjecture that cardiac dynamics of normal control mice has both deterministic and stochastic elements, is nonstationary, nonlinear, and exerts multifractal properties. Central application of CRF results in bradycardia and increased variability of the beat-to-beat fluctuations. The altered dynamical properties elicited by CRF reflect a significant loss of intrinsic structural complexity of cardiac control which is due to central neuroautonomic hyperexcitation, i.e., enhanced sympatho-vagal antagonism. The change in dynamical complexity is characterized by an effect referred to as fractal rigidity, leading to a significant impairment of adaptability to extrinsic challenges in a fluctuating environment. The impact of dynamical neurocardiopathy as a major precipiting factor for the propensity of cardiac arrhythmias or sudden cardiac death by unchecked central CRF release in significant acute life events in man is critically discussed.
促肾上腺皮质激素释放因子对心脏压力反射的中枢自主调节。
DOI：
10.1152/ajpheart.1989.256.4.h949
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Fisher,LA
通讯作者：
Fisher,LA
DOI：
10.1209/epl/i1998-00366-3
发表时间：
1998-08-15
期刊：
EUROPHYSICS LETTERS
影响因子：
--
作者：
Ivanov, PC;Amaral, LAN;Stanley, HE
通讯作者：
Stanley, HE
影响因子：
8.6
作者：
Amaral, LAN;Ivanov, PC;Yamamoto, Y
通讯作者：
Yamamoto, Y