The antihypertensive effect of remote ischemic conditioning in spontaneously hypertensive rats.
The antihypertensive effect of remote ischemic conditioning in spontaneously hypertensive rats.
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远程缺血性调节在自发性高血压大鼠中的降压作用。
DOI：
10.3389/fimmu.2022.1093262
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发表时间：
2022
影响因子：
7.3
通讯作者：
Ji, Xunming
中科院分区：
文献类型：
--
作者：
Li, Xiaohua;Ren, Changhong;Li, Sijie;Zhao, Wenbo;Wang, Peifu;Ji, Xunming
肢体远端缺血预处理（LRIC）可能是控制高血压的有效方法。本研究探讨LRIC是否通过调节自发性高血压大鼠（SHR）的高血压炎症反应降低血压。将不同年龄的SHR和Wistar大鼠随机分为SHR组、SHR+LRIC组、Wistar组和Wistar + LRIC组。LRIC通过收紧大腿上部周围的止血带并释放止血带进行，每天三个周期（10分钟x3个周期）。分析血压、单核细胞和T淋巴细胞的百分比以及血液中促炎细胞因子的浓度。SHR的血压明显高于同龄Wistar大鼠。LRIC可降低4、8、16周龄SHR的血压，但对Wistar大鼠的血压无影响。流式细胞仪分析表明，SHR的血液单核细胞和CD 8 T细胞高于Wistar大鼠。LRIC显著降低SHR单核细胞和CD 8 T细胞的百分比。与免疫细胞的变化一致，SHR血浆IL-6和TNF-α水平也升高。LRIC可降低SHR血浆IL-6和TNF-α水平。LRIC可能通过调节SHR的炎症反应而降低血压。
Limb remote ischemic conditioning (LRIC) may be an effective method to control hypertension. This study investigated whether LRIC decreases blood pressure by regulating the hypertensive inflammatory response in spontaneously hypertensive rats (SHR). The SHR and aged-matched Wistar rats with different ages were randomly assigned to the SHR group, SHR+LRIC group, Wistar group, and Wistar + LRIC group. LRIC was conducted by tightening a tourniquet around the upper thigh and releasing it for three cycles daily (10 mins x3 cycles). Blood pressure, the percentage of monocytes and T lymphocytes, and the concentration of pro-inflammatory cytokines in the blood were analyzed. The blood pressure of SHR was significantly higher than that of age-matched Wistar rats. LRIC decreased blood pressure in SHR at different ages (4, 8, and 16 weeks old), but had no effect on the blood pressure in Wistar rats. Flow cytometry analysis showed that blood monocytes and CD8 T cells of SHR were higher than those of Wistar rats. LRIC significantly decreased the percentage of monocytes and CD8 T cells in SHR. Consistent with the changes of immune cells, the levels of plasma IL-6 and TNF-α in SHR were also higher. And LRIC attenuated the plasma IL-6 and TNF-α levels in SHR. LRIC may decreased the blood pressure via modulation of the inflammatory response in SHR.
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DOI：
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发表时间：
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期刊：
Journal of inflammation (London, England)
影响因子：
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