Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections.
Systematic review of clinical trials assessing the effectiveness of ivy leaf (hedera helix) for acute upper respiratory tract infections.
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DOI：
10.1155/2011/382789
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Chenot JF
中科院分区：
文献类型：
--
作者：
Holzinger F;Chenot JF
导论.在非抗生素咳嗽治疗中，含有常春藤叶提取物的草药制剂非常受欢迎。Objective.一项评估常春藤治疗急性上呼吸道感染（URTI）的有效性和耐受性的系统评价。方法.我们检索了随机对照试验（RCT）、非随机对照临床试验和观察性研究，以评价常春藤制剂治疗急性URTI的疗效。通过Jadad评分或EPHPP工具评估研究质量。结果确定了10项合格研究，报告了17463例受试者。研究在设计和实施方面具有异质性; 2项为RCT。3项研究评估了常春藤和百里香的组合，7项研究调查了常春藤的替代品。只有一项研究常春藤/百里香组合的RCT（n = 360）使用安慰剂对照，在减少咳嗽频率和持续时间方面显示出统计学显著的优越性。所有其他研究都缺乏安慰剂对照，并显示出严重的方法学缺陷。他们都得出结论，常春藤提取物对减轻URTI症状有效。结论虽然所有的研究都报告常春藤提取物可以有效地减轻URTI的症状，但由于严重的方法缺陷和缺乏安慰剂对照，没有令人信服的证据。常春藤和百里香的组合可能更有效，但需要确认。
Introduction. Among nonantibiotic cough remedies, herbal preparations containing extracts from leaves of ivy (Hedera helix) enjoy great popularity. Objective. A systematic review to assess the effectiveness and tolerability of ivy for acute upper respiratory tract infections (URTIs). Methods. We searched for randomized controlled trials (RCTs), nonrandomized controlled clinical trials and observational studies evaluating the efficacy of ivy preparations for acute URTIs. Study quality was assessed by the Jadad score or the EPHPP tool. Results. 10 eligible studies were identified reporting on 17463 subjects. Studies were heterogeneous in design and conduct; 2 were RCTs. Three studies evaluated a combination of ivy and thyme, 7 studies investigated monopreparations of ivy. Only one RCT (n = 360) investigating an ivy/thyme combination used a placebo control and showed statistically significant superiority in reducing the frequency and duration of cough. All other studies lack a placebo control and show serious methodological flaws. They all conclude that ivy extracts are effective for reducing symptoms of URTI. Conclusion. Although all studies report that ivy extracts are effective to reduce symptoms of URTI, there is no convincing evidence due to serious methodological flaws and lack of placebo controls. The combination of ivy and thyme might be more effective but needs confirmation.
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影响因子：
--
作者：
Fahey, T;Stocks, N;Thomas, T
通讯作者：
Thomas, T
影响因子：
7.9
作者：
Gepdiremen, A;Mshvildadze, V;Elias, R
通讯作者：
Elias, R
影响因子：
10
作者：
Huntley, A;Ernst, E
通讯作者：
Ernst, E
DOI：
10.1016/0197-2456(95)00134-4
发表时间：
1996-02-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Jadad, AR;Moore, RA;McQuay, HJ
通讯作者：
McQuay, HJ
影响因子：
2.2
作者：
Hak, E.;Rovers, M. M.;Verheij, T. J. M.
通讯作者：
Verheij, T. J. M.