Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice.
Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice.
复制标题
DOI：
10.1038/s41598-017-07511-2
复制
发表时间：
2017-08-03
影响因子：
4.6
通讯作者：
Ignatius A
中科院分区：
文献类型：
--
作者：
Fischer V;Haffner-Luntzer M;Prystaz K;Vom Scheidt A;Busse B;Schinke T;Amling M;Ignatius A
钙和维生素D（Ca/VitD）缺乏是骨质疏松症的主要危险因素。它也可能有助于在骨质疏松患者中经常观察到的骨愈合受损，因为钙对骨痂矿化至关重要。此外，临床数据表明骨折后全身性骨丢失，这可能会加重骨质疏松症，从而进一步增加骨质疏松症患者发生脆性骨折的风险。然而，钙/维生素D在骨折愈合和创伤后骨转换中的作用迄今为止研究甚少。在这里，我们研究了骨再生和创伤后骨转换与卵巢切除诱导骨质疏松症的C57 BL/6 J小鼠。给小鼠喂食标准或Ca/VitD缺乏的饮食。值得注意的是，骨折愈合只是轻微干扰钙/维生素D缺乏小鼠。然而，缺乏小鼠显示显着增加血清甲状旁腺激素水平和破骨细胞活性，以及减少骨量在骨折后的完整骨骼，这表明在骨再生过程中从完整的骨骼大大增强钙动员。骨折后开始补充Ca/VitD可通过减少骨吸收防止创伤后骨丢失，进而改善骨修复。这些结果表明，骨折后足够的Ca/VitD供应是必不可少的，以提供足够的钙为愈伤组织矿化，以防止创伤后骨丢失，并降低继发性骨折的风险，钙/VitD缺乏的骨质疏松症患者。
Calcium and vitamin-D (Ca/VitD) deficiency is a major risk factor for osteoporosis. It may also contribute to the compromised bone healing frequently observed in osteoporotic patients, since calcium is essential for fracture-callus mineralization. Additionally, clinical data suggest systemic bone loss following fracture, which may aggravate osteoporosis and thus increase the risk for fragility fractures in osteoporotic patients further. However, the role of Ca/VitD in fracture healing and posttraumatic bone turnover has to date been poorly investigated. Here, we studied bone regeneration and posttraumatic bone turnover in C57BL/6 J mice with ovariectomy-induced osteoporosis. Mice were fed a standard or a Ca/VitD-deficient diet. Notably, fracture healing was only marginally disturbed in Ca/VitD-deficient mice. However, deficient mice displayed significantly increased serum parathyroid hormone levels and osteoclast activity, as well as reduced bone mass in the intact skeleton post-fracture, suggesting considerably enhanced calcium mobilization from the intact skeleton during bone regeneration. Ca/VitD supplementation initiated post-fracture prevented posttraumatic bone loss by reducing bone resorption and furthermore improved bone repair. These results imply that adequate Ca/VitD supply post-fracture is essential to provide sufficient calcium for callus-mineralization in order to prevent posttraumatic bone loss and to reduce the risk for secondary fractures in osteoporotic patients with Ca/VitD deficiency.
登录
查看更多内容
影响因子：
4.1
作者：
Follin, SL;Black, JN;McDermott, MT
通讯作者：
McDermott, MT
影响因子：
3.7
作者：
Haffner-Luntzer M;Kemmler J;Heidler V;Prystaz K;Schinke T;Amling M;Kovtun A;Rapp AE;Ignatius A;Liedert A
通讯作者：
Liedert A
影响因子：
7.1
作者：
Hitz, Mette F.;Jensen, Jens-Erik B.;Eskildsen, Peter C.
通讯作者：
Eskildsen, Peter C.
影响因子：
1.8
作者：
Han, SM;Szarzanowicz, TE;Ziv, I
通讯作者：
Ziv, I
影响因子：
4.1
作者：
Busse, Bjoern;Hahn, Michael;Amling, Michael
通讯作者：
Amling, Michael