Updates on ion and water transport by the Malpighian tubule.

Updates on ion and water transport by the Malpighian tubule.
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DOI:
10.1016/j.cois.2021.02.018
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发表时间:
2021-10
影响因子:
5.3
通讯作者:
--
中科院分区:
农林科学2区
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--
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马尔皮基氏管(肾)小管能够以显著的速率运输液体。本文将重点介绍最近的见解,这些高利率的实现和控制的机制,特别是指果蝇的小管,在生理学和遗传学的结合,导致特别迅速的进展。像许多脊椎动物的上皮细胞一样,果蝇的小管有专门的细胞类型,阳离子运输活跃,局限于一个大的,代谢活跃的主细胞;而较小的嵌入星状细胞控制氯和水分流,以实现净液体分泌。最近,许多这些过程的基因已被确定,功能验证和本地化的小管。新类型的后基因组数据(特别是单细胞测序)即将到来,这将预示着一个令人兴奋的新发现时代的到来。
The Malpighian (renal) tubule is capable of transporting fluid at remarkable rates. This review will focus on recent insights into the mechanisms by which these high rates are achieved and controlled, with particular reference to the tubules of Drosophila melanogaster, in which the combination of physiology and genetics has led to particularly rapid progress. Like many vertebrate epithelia, the Drosophila tubule has specialized cell types, with active cation transport confined to a large, metabolically active principal cell; whereas the smaller intercalated stellate cell controls chloride and water shunts to achieve net fluid secretion. Recently, the genes underlying many of these processes have been identified, functionally validated and localized within the tubule. The imminent arrival of new types of post-genomic data (notably single cell sequencing) will herald an exciting era of new discovery.
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