Updates on ion and water transport by the Malpighian tubule.
Updates on ion and water transport by the Malpighian tubule.
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DOI:
10.1016/j.cois.2021.02.018
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发表时间:
2021-10
影响因子:
5.3
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中科院分区:
文献类型:
--
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The Malpighian (renal) tubule is capable of transporting fluid at remarkable rates. This review will focus on recent insights into the mechanisms by which these high rates are achieved and controlled, with particular reference to the tubules of Drosophila melanogaster, in which the combination of physiology and genetics has led to particularly rapid progress. Like many vertebrate epithelia, the Drosophila tubule has specialized cell types, with active cation transport confined to a large, metabolically active principal cell; whereas the smaller intercalated stellate cell controls chloride and water shunts to achieve net fluid secretion. Recently, the genes underlying many of these processes have been identified, functionally validated and localized within the tubule. The imminent arrival of new types of post-genomic data (notably single cell sequencing) will herald an exciting era of new discovery.
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DOI:
10.1242/dev.088989
发表时间:
2013-03
期刊:
Development (Cambridge, England)
影响因子:
--
作者:
Denholm B;Hu N;Fauquier T;Caubit X;Fasano L;Skaer H
通讯作者:
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DOI:
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发表时间:
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期刊:
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影响因子:
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作者:
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通讯作者:
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影响因子:
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