Risk of cancer associated with low-dose radiation exposure: comparison of results between the INWORKS nuclear workers study and the A-bomb survivors study.
Risk of cancer associated with low-dose radiation exposure: comparison of results between the INWORKS nuclear workers study and the A-bomb survivors study.
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与低剂量辐射暴露相关的癌症风险：INWORKS核工人研究与原子弹幸存者研究结果的比较。
DOI：
10.1007/s00411-020-00890-7
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发表时间：
2021-03
影响因子：
1.7
通讯作者：
Laurier D
中科院分区：
文献类型：
--
作者：
Leuraud K;Richardson DB;Cardis E;Daniels RD;Gillies M;Haylock R;Moissonnier M;Schubauer-Berigan MK;Thierry-Chef I;Kesminiene A;Laurier D
日本原子弹幸存者的寿命研究(LSS)一直是评估辐射相关疾病风险的主要基础，这些风险为辐射防护标准提供了依据。对受辐射监测的核工作人员的长期跟踪提供了对辐射与癌症相关性的估计，补充了LSS的发现。在这里，提供了从LSS和INWORKS得出的辐射-癌症死亡风险估计的比较，INWORKS是一项大型国际核工作者研究。进行了限制，以便两个研究人群在年龄和暴露时间方面相似，从而选择了45,625名A弹幸存者和259,350名核工作人员。对于实体癌，LSS和INWORKS的超额相对比率(ERR)分别为0.28(90%CI为0.18；0.38)和0.29(90%CI为0.07；0.53)。通过对数据的联合分析，可以对两项研究中每GyERR的异质性进行正式评估(P=0.909)，而在两项研究中，弯曲度或年龄、暴露年龄或性别的改变效果最小。这两个队列中都有证据表明，随着年龄的增长，实体癌的超额绝对风险(EAR)有增加的趋势。对于白血病，在一个简单的线性模型下，LSS和INWORKS的每GyERR分别为2.75(90%CI 1.73；4.21)和3.15(90%CI 1.12；5.72)，在LSS中观察到的剂量范围内有明显的弯曲，而INWORKS中没有；每GyLSS的ERR为3.54(90%CI 2.30；5.05)，INWORKS为2.03(90%CI 0.36；4.07)。这些来自不同研究人群的发现可能有助于理解辐射风险，INWORKS提供了来自长期低剂量率暴露的工人队列的信息。
The Life Span Study (LSS) of Japanese atomic bomb survivors has served as the primary basis for estimates of radiation-related disease risks that inform radiation protection standards. The long-term follow-up of radiation-monitored nuclear workers provides estimates of radiation-cancer associations that complement findings from the LSS. Here, a comparison of radiation-cancer mortality risk estimates derived from the LSS and INWORKS, a large international nuclear worker study, is presented. Restrictions were made, so that the two study populations were similar with respect to ages and periods of exposure, leading to selection of 45,625 A-bomb survivors and 259,350 nuclear workers. For solid cancer, excess relative rates (ERR) per gray (Gy) were 0.28 (90% CI 0.18; 0.38) in the LSS, and 0.29 (90% CI 0.07; 0.53) in INWORKS. A joint analysis of the data allowed for a formal assessment of heterogeneity of the ERR per Gy across the two studies (P = 0.909), with minimal evidence of curvature or of a modifying effect of attained age, age at exposure, or sex in either study. There was evidence in both cohorts of modification of the excess absolute risk (EAR) of solid cancer by attained age, with a trend of increasing EAR per Gy with attained age. For leukemia, under a simple linear model, the ERR per Gy was 2.75 (90% CI 1.73; 4.21) in the LSS and 3.15 (90% CI 1.12; 5.72) in INWORKS, with evidence of curvature in the association across the range of dose observed in the LSS but not in INWORKS; the EAR per Gy was 3.54 (90% CI 2.30; 5.05) in the LSS and 2.03 (90% CI 0.36; 4.07) in INWORKS. These findings from different study populations may help understanding of radiation risks, with INWORKS contributing information derived from cohorts of workers with protracted low dose-rate exposures.
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影响因子：
2.2
作者：
Cullings, H. M.;Grant, E. J.;Kodama, K.
通讯作者：
Kodama, K.
影响因子：
3.4
作者：
Cordova, Kismet A.;Cullings, Harry M.
通讯作者：
Cullings, Harry M.
影响因子：
7.7
作者：
Hamra GB;Richardson DB;Cardis E;Daniels RD;Gillies M;O'Hagan JA;Haylock R;Laurier D;Leuraud K;Moissonnier M;Schubauer-Berigan M;Thierry-Chef I;Kesminiene A
通讯作者：
Kesminiene A
影响因子：
1.5
作者：
Chadwick, K. H.
通讯作者：
Chadwick, K. H.
影响因子：
2.6
作者：
Hoel, David G.
通讯作者：
Hoel, David G.