The hypertriglyceridemic waist phenotype is associated with fatty liver and glycometabolic profiles in overweight and obese adults: a cross-sectional study.
The hypertriglyceridemic waist phenotype is associated with fatty liver and glycometabolic profiles in overweight and obese adults: a cross-sectional study.
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高甘油三酯腰部表型与超重和肥胖成人的脂肪肝和糖代谢特征相关：一项横断面研究
DOI：
10.1038/s41598-021-00825-2
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发表时间：
2022-02-14
影响因子：
4.6
通讯作者：
Baker JS
中科院分区：
文献类型：
--
作者：
Zhou M;Li F;Tang H;Wu S;Meng L;Dong Y;Wang F;Quach B;Yang Y;Ma J;Baker JS
本研究旨在区分超重/肥胖成年人不同的高甘油三酯血症腰部表型及其发生脂肪肝和糖代谢异常的相关风险。中国成年人1221例，平均年龄37(9)岁，男性37.3%，女性62.7%，体重指数29.0(4.0)kg/m2，甘油三酯2.04(1.45)mmol/L，腰围95.8(10.7)cm，分为4种表型：正常TG+正常WC(N-N)、正常TG+高WC(N-WC)、高TG+正常WC(TG-N)；高Tg高WC(Tg-WC)。TG-WC组的BMI、WC、血压(BP)、胰岛素、胰岛素抵抗(HOMA-IR)、糖化血红蛋白(HbA1c)、低密度脂蛋白胆固醇(LDL)和脂肪肝最高。N-WC组的参与者患脂肪肝的风险显著增加(调整OR 3.50[95%CI 2.05-5.97])、TG-N(调整OR 2.59[95%CI 1.61-4.16])和TG-WC(调整OR 4.12[95%CI 2.28-7.46])。TG-N(调整OR 2.16[95%CI 1.33-3.50])和TG-WC(调整OR 2.04[95%CI 1.22-3.40])患者HOMA-IR升高的风险显著增加。在TG-WC组，HbA1c升高的风险显著增加(调整后的OR2.79[95%CI 1.47-5.31])。高甘油三酯血症腰部表型可能是一种潜在的、经济有效的方法来识别脂肪肝和糖代谢紊乱的高危个体。
The present study aimed to distinguish different hypertriglyceridemic waist phenotypes and relevant risks of developing fatty liver and abnormal glycometabolic profiles in overweight/obese adults. A total of 1221 Chinese adults with mean (standard deviation [SD]) age of 37 (9) years, 37.3% males and 62.7% females, body mass index (BMI) of 29.0 (4.0) kg/m2, triglyceride (TG) 2.04 (1.45) mmol/L, and waist circumference (WC) 95.8 (10.7) cm were included and classified into four phenotypes: normal TG & normal WC (N-N); normal TG & high WC (N-WC); high TG & normal WC (TG-N); high TG & high WC (TG-WC). Participants in TG-WC group had the highest BMI, WC, blood pressure (BP), insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), glycosylated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL), and fatty liver. Participants within N-WC group had a significantly higher risk of fatty liver (adjusted OR 3.50 [95% CI 2.05–5.97]), as well as TG-N (adjusted OR 2.59 [95% CI 1.61–4.16]) and TG-WC (adjusted OR 4.12 [95% CI 2.28–7.46]). The risk of elevated HOMA-IR was significantly higher in TG-N (adjusted OR 2.16 [95% CI 1.33–3.50]) and TG-WC (adjusted OR 2.04 [95% CI 1.22–3.40]). The risk of elevated HbA1c was significantly higher in the TG-WC (adjusted OR 2.79 [95% CI 1.47–5.31]). Hypertriglyceridemic waist phenotype can be a potential and cost-effective method to identify individuals with a high risk of fatty liver and glycometabolic disorders.
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影响因子：
8.2
作者：
Batista TM;Haider N;Kahn CR
通讯作者：
Kahn CR
影响因子：
2.1
作者：
Namdarimoghaddam P;Fowokan A;Humphries KH;Mancini GBJ;Lear S
通讯作者：
Lear S
影响因子：
37.8
作者：
Lemieux, I;Pascot, A;Després, JP
通讯作者：
Després, JP
影响因子：
168.9
作者：
Kahn, Steven E.;Cooper, Mark E.;Del Prato, Stefano
通讯作者：
Del Prato, Stefano
影响因子：
4.8
作者：
Santos A;Magro DO;Evangelista-Poderoso R;Saad MJA
通讯作者：
Saad MJA