Association of "hypertriglyceridemic waist" with increased 5-year risk of subclinical atherosclerosis in a multi-ethnic population: a prospective cohort study.
Association of "hypertriglyceridemic waist" with increased 5-year risk of subclinical atherosclerosis in a multi-ethnic population: a prospective cohort study.
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DOI：
10.1186/s12872-021-01882-1
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发表时间：
2021-02-02
影响因子：
2.1
通讯作者：
Lear S
中科院分区：
文献类型：
--
作者：
Namdarimoghaddam P;Fowokan A;Humphries KH;Mancini GBJ;Lear S
高甘油三酯血症腰围(HTGW)结合了腰围和血液中甘油三酯水平的测量，可以作为早期预测指标，以识别亚临床动脉粥样硬化的高危个体。以前的研究已经探索了HTGW和动脉粥样硬化之间的横截面关联；然而，了解这种关联如何随着时间的推移而变化是必要的。本研究将评估HTGW与5年亚临床颈动脉粥样硬化的关系。对517名原住民、中国人、欧洲人和南亚人的参与者进行了基线HTGW和5年亚临床动脉粥样硬化指数(内膜中层厚度(Mm)、总面积(Mm2)和斑块存在情况)的检查。将心血管疾病家族史、社会人口学指标(年龄、性别、种族、收入水平、最高教育程度)和传统危险因素(收缩压、吸烟状况、总胆固醇、高密度脂蛋白胆固醇、体重指数)纳入关联模型。这些模型使用了多元线性回归和Logistic回归。与非HTGW组相比，基线HTGW表型是5年内膜中层厚度(β = 0.08[0.04，0.11]，p <； 0.001)、总面积(β = 0.20[0.07，0.33]，p = 0.002)和斑块存在(OR = 2.17[1.13，4.19]，p = 0.02)的有统计学意义和临床意义的预测因子，独立于社会人口学因素和家族史。然而，在调整了动脉粥样硬化的传统危险因素后，这种相关性不再显著(分别为p = 0.27，p = 0.45，p = 0.66)。此外，HTGW表型状态的改变与5年内动脉粥样硬化指数的改变无关。我们的结果表明，当动脉粥样硬化的传统危险因素已知时，HTGW可能不会作为亚临床动脉粥样硬化进展的5年内的预测指标提供额外的价值。
Hypertriglyceridemic waist (HTGW), which incorporates measures of waist circumference and levels of triglyceride in blood, could act as an early-stage predictor to identify the individuals at high-risk for subclinical atherosclerosis. Previous studies have explored the cross-sectional association between HTGW and atherosclerosis; however, understanding how this association might change over time is necessary. This study will assess the association between HTGW with 5-year subclinical carotid atherosclerosis. 517 participants of Aboriginal, Chinese, European, and South Asian ethnicities were examined for baseline HTGW and 5-year indices of subclinical atherosclerosis (intima media thickness (mm), total area (mm2), and plaque presence). Family history of cardiovascular disease, sociodemographic measures (age, sex, ethnicity, income level, maximum education), and traditional risk factors (systolic blood pressure, smoking status, total cholesterol, high-density lipoprotein cholesterol, body mass index) were incorporated into the models of association. These models used multiple linear regression and logistic regression. Baseline HTGW phenotype is a statistically significant and clinically meaningful predictor of 5-year intima media thickness (β = 0.08 [0.04, 0.11], p < 0.001), total area (β = 0.20 [0.07, 0.33], p = 0.002), and plaque presence (OR = 2.17 [1.13, 4.19], p = 0.02) compared to the non-HTGW group independent of sociodemographic factors and family history. However, this association is no longer significant after adjusting for the traditional risk factors of atherosclerosis (p = 0.27, p = 0.45, p = 0.66, respectively). Moreover, change in status of HTGW phenotype does not correlate with change in indices of atherosclerosis over 5 years. Our results suggest that when the traditional risk factors of atherosclerosis are known, HTGW may not offer additional value as a predictor of subclinical atherosclerosis progression over 5 years.
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影响因子：
37.8
作者：
Lemieux, I;Pascot, A;Després, JP
通讯作者：
Després, JP
影响因子：
3.3
作者：
Kelishadi, Roya;Jamshidi, Fahimeh;Hovsepian, Silva
通讯作者：
Hovsepian, Silva
影响因子：
1.4
作者：
Calcaterra, Valeria;De Giuseppe, Rachele;Cena, Hellas
通讯作者：
Cena, Hellas
DOI：
10.3803/enm.2014.29.4.514
发表时间：
2014-12-29
期刊：
Endocrinology and metabolism (Seoul, Korea)
影响因子：
--
作者：
Han KJ;Lee SY;Kim NH;Chae HB;Lee TH;Jang CM;Yoo KM;Park HJ;Lee MK;Jeon WS;Park SE;Park CY;Lee WY;Oh KW;Park SW;Rhee EJ
通讯作者：
Rhee EJ
影响因子：
4.9
作者：
Czernichow, S.;Bruckert, E.;Oppert, J-M
通讯作者：
Oppert, J-M