Disrupted expected value and prediction error signaling in youths with disruptive behavior disorders during a passive avoidance task.
Disrupted expected value and prediction error signaling in youths with disruptive behavior disorders during a passive avoidance task.
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DOI：
10.1176/appi.ajp.2012.12060840
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Blair RJ
中科院分区：
文献类型：
--
作者：
White SF;Pope K;Sinclair S;Fowler KA;Brislin SJ;Williams WC;Pine DS;Blair RJ
具有破坏性行为障碍的青少年，包括行为障碍和对立违抗性障碍，在基于认知的决策中表现出重大障碍。然而，这些困难的神经基础仍然知之甚少。这在一定程度上反映了以前在决策和反馈处理过程中区分反应以及利用基于计算模型的功能性MRI（fMRI）的失败。参与者为38名10-18岁的社区青少年（20名有破坏性行为障碍，18名为健康对照青少年）。基于模型的功能磁共振成像被用来评估腹内侧前额叶皮层，小脑和尾状核的决策和反馈处理所涉及的计算过程。具有破坏性行为障碍的青少年在选择回应时，在腹内侧前额叶皮层内使用期望值信息的情况减少，而在选择不回应时，在前额叶皮层内使用期望值信息的情况减少。此外，在反馈过程中，他们对尾状核内的阳性预测错误的反应性降低，对阴性预测错误的反应性增加。这项研究是第一个确定损伤的使用期望值在腹内侧前额叶皮层和脑皮层在选择和预测错误信号在尾状核在反馈过程中的破坏性行为障碍的青少年。
Youths with disruptive behavior disorders, including conduct disorder and oppositional defiant disorder, show major impairments in reinforcement-based decision making. However, the neural basis of these difficulties remains poorly understood. This partly reflects previous failures to differentiate responses during decision making and feedback processing and to take advantage of computational model-based functional MRI (fMRI). Participants were 38 community youths ages 10–18 (20 had disruptive behavior disorders, and 18 were healthy comparison youths). Model-based fMRI was used to assess the computational processes involved in decision making and feedback processing in the ventromedial prefrontal cortex, insula, and caudate. Youths with disruptive behavior disorders showed reduced use of expected value information within the ventromedial prefrontal cortex when choosing to respond and within the anterior insula when choosing not to respond. In addition, they showed reduced responsiveness to positive prediction errors and increased responsiveness to negative prediction errors within the caudate during feedback. This study is the first to determine impairments in the use of expected value within the ventromedial prefrontal cortex and insula during choice and in prediction error-signaling within the caudate during feedback in youths with disruptive behavior disorders.
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DOI：
10.1196/annals.1390.022
发表时间：
2007-01-01
期刊：
REWARD AND DECISION MAKING IN CORTICOBASAL GANGLIA NETWORKS
影响因子：
--
作者：
O'Doherty, John P.;Hampton, Alan;Kim, Hackjin
通讯作者：
Kim, Hackjin
DOI：
10.1073/pnas.1014457108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Enomoto, Kazuki;Matsumoto, Naoyuki;Kimura, Minoru
通讯作者：
Kimura, Minoru
影响因子：
3.6
作者：
Blair, RJR;Colledge, E;Mitchell, DGV
通讯作者：
Mitchell, DGV
影响因子：
4.6
作者：
Fergusson, David M.;Boden, Joseph M.;Horwood, L. John
通讯作者：
Horwood, L. John
影响因子：
17.7
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Blair, R. J. R.
通讯作者：
Blair, R. J. R.