Early development of the skin microbiome: therapeutic opportunities.
Early development of the skin microbiome: therapeutic opportunities.
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DOI：
10.1038/s41390-020-01146-2
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发表时间：
2021-10
影响因子：
3.6
通讯作者：
Paller AS
中科院分区：
文献类型：
--
作者：
Casterline BW;Paller AS
由于人类皮肤在健康和疾病中拥有不同的微生物群，因此正在形成一种共识，即宿主和微生物群之间的失调相互作用可能导致皮肤的慢性炎症性疾病。新生儿皮肤是一个独特的栖息地，结构上与成人相似，但具有不同的代谢底物，环境应激源和免疫活性。表面是殖民化的时刻内出生的偏向母亲的菌株。随着环境暴露的增加和宿主皮肤的成熟，最初的殖民者被击败。尽管如此，生命早期的微生物收购可能通过调节宿主免疫力和细菌之间的竞争性相互作用对健康产生长期持久的影响。50多年来，皮肤科医生一直对微生物生态学及其对健康的影响感兴趣，最近对微生物组的兴趣激增，促使人们对皮肤病的几种微生物疗法进行了持续研究。在这篇综述中，我们考虑了最近对宿主和微生物因素的深入了解如何在生命早期驱动皮肤微生物组的发展，为治疗干预提供了新的机会。
As human skin hosts a diverse microbiota in health and disease, there is an emerging consensus that dysregulated interactions between host and microbiome may contribute to chronic inflammatory disease of the skin. Neonatal skin is a unique habitat, structurally similar to the adult but with a different profile of metabolic substrates, environmental stressors, and immune activity. The surface is colonized within moments of birth with a bias toward maternal strains. Initial colonists are outcompeted as environmental exposures increase and host skin matures. Nonetheless, early life microbial acquisitions may have long lasting effects on health through modulation of host immunity and competitive interactions between bacteria. Microbial ecology and its influence on health has been of interest to dermatologists for more than 50 years, and an explosion of recent interest in the microbiome has prompted ongoing investigations of several microbial therapeutics for dermatological disease. In this review, we consider how recent insight into the host and microbial factors driving development of the skin microbiome in early life offers new opportunities for therapeutic intervention.
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DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
6.5
作者：
Capone, Kimberly A.;Dowd, Scot E.;Stamatas, Georgios N.;Nikolovski, Janeta
通讯作者：
Nikolovski, Janeta
DOI：
10.1126/science.aax6624
发表时间：
2019-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
Belkaid Y
DOI：
10.1073/pnas.78.10.6324
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
CHAO, L;LEVIN, BR
通讯作者：
LEVIN, BR
影响因子：
4.4
作者：
Christensen, Gitte J. M.;Scholz, Christian F. P.;Bruggemann, Holger
通讯作者：
Bruggemann, Holger