Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster.
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster.
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DOI：
10.1534/genetics.118.300224
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发表时间：
2018-10
期刊：
影响因子：
3.3
通讯作者：
Lemaitre B
中科院分区：
文献类型：
--
作者：
Miguel-Aliaga I;Jasper H;Lemaitre B
胃肠道最近已成为多个研究领域的前沿。它现在被认为是调节食物摄入，胰岛素分泌和能量平衡的信号的主要来源。它也是免疫的关键参与者，通过与微生物群的相互作用，可以以复杂且有时意想不到的方式塑造我们的生理和行为。相比之下，昆虫的肠道一直相对未被探索，直到十多年前在果蝇肠道中鉴定出成体干细胞。从那时起，越来越多的科学界以强大而创造性的方式利用了这种昆虫器官的遗传顺从性。通过这样做，我们揭示了围绕干细胞及其利基，器官间信号传导和免疫的广泛生物学问题。尽管它们相对较新的发现，但在苍蝇肠道中活跃的一些机制已经被证明更广泛地适用于其他胃肠道系统，因此可能与人类病理学（如胃肠道癌症、衰老或肥胖）相关。本文综述了果蝇消化道的形成和功能，主要集中在其主要的消化/吸收部分：适应性强的成年中肠。
The gastrointestinal tract has recently come to the forefront of multiple research fields. It is now recognized as a major source of signals modulating food intake, insulin secretion and energy balance. It is also a key player in immunity and, through its interaction with microbiota, can shape our physiology and behavior in complex and sometimes unexpected ways. The insect intestine had remained, by comparison, relatively unexplored until the identification of adult somatic stem cells in the Drosophila intestine over a decade ago. Since then, a growing scientific community has exploited the genetic amenability of this insect organ in powerful and creative ways. By doing so, we have shed light on a broad range of biological questions revolving around stem cells and their niches, interorgan signaling and immunity. Despite their relatively recent discovery, some of the mechanisms active in the intestine of flies have already been shown to be more widely applicable to other gastrointestinal systems, and may therefore become relevant in the context of human pathologies such as gastrointestinal cancers, aging, or obesity. This review summarizes our current knowledge of both the formation and function of the Drosophila melanogaster digestive tract, with a major focus on its main digestive/absorptive portion: the strikingly adaptable adult midgut.
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DOI：
10.1083/jcb.201103018
发表时间：
2011-05-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Amcheslavsky A;Ito N;Jiang J;Ip YT
通讯作者：
Ip YT
影响因子：
11.4
作者：
Balamurugan, Kuppusamy;Egli, Dieter;Schaffner, Walter
通讯作者：
Schaffner, Walter
影响因子：
2.4
作者：
Baechler BL;McKnight C;Pruchnicki PC;Biro NA;Reed BH
通讯作者：
Reed BH
影响因子：
7.7
作者：
Basset, A;Tzou, P;Boccard, F
通讯作者：
Boccard, F
影响因子：
4.6
作者：
Beehler-Evans, Ryan;Micchelli, Craig A.
通讯作者：
Micchelli, Craig A.