In vitro validation of finite-element model of AAA hemodynamics incorporating realistic outlet boundary conditions.
In vitro validation of finite-element model of AAA hemodynamics incorporating realistic outlet boundary conditions.
复制标题
结合真实出口边界条件的 AAA 血流动力学有限元模型的体外验证。
DOI：
10.1115/1.4003526
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Taylor CA
中科院分区：
文献类型：
--
作者：
Kung EO;Les AS;Medina F;Wicker RB;McConnell MV;Taylor CA
利用相位对比磁共振成像(PCMRI)对腹主动脉瘤(AAA)和体外体模在生理流动和压力条件下的流动和压力进行数值模拟。我们根据AAA患者的影像数据构建了一个双出口物理流动体模，并发展了一个物理Windkesel模型作为出口边界条件。然后，我们在模拟休息和轻微运动生理状态的条件下运行时，获取了模型中的PCMRI数据。接下来，我们进行了硅内数值模拟，并将实验测量的体外体模中的速度、流量和压力与硅内模拟中计算的速度、流量和压力进行了比较。实验测量结果与模拟结果之间的压力和流动波形及大小高度吻合。实验和模拟的平均压力和流量分流差均在2%以内。速度分布与实验测量结果吻合较好，特别是在全周期平均比较的情况下。我们演示了使用生理流动和压力进行体外体模实验的方法，在复杂的、患者特定的AAA几何结构中，显示了数值模拟和实验测量的速度场和压力波形之间的良好一致性。
To validate numerical simulations of flow and pressure in an abdominal aortic aneurysm (AAA) using phase-contrast MRI (PCMRI), and an in-vitro phantom under physiological flow and pressure conditions. We constructed a 2-outlet physical flow phantom based on patient imaging data of an AAA, and developed a physical Windkessel model to use as outlet boundary conditions. We then acquired PCMRI data in the phantom while it operated under conditions mimicking a resting and a light exercise physiological state. Next, we performed in-silico numerical simulations, and compared experimentally measured velocities, flows, and pressures in the in-vitro phantom to those computed in the in-silico simulations. There was a high degree of agreement in all of the pressure and flow waveform shapes and magnitudes between the experimental measurements and simulated results. The average pressures and flow split difference between experiment and simulation were all within 2%. Velocity patterns showed good agreement between experimental measurements and simulated results, especially in the case of whole-cycle averaged comparisons. We demonstrated methods to perform in-vitro phantom experiments with physiological flows and pressures, showing good agreement between numerically simulated and experimentally measured velocity fields and pressure waveforms in a complex, patient-specific AAA geometry.
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DOI：
10.1016/j.cma.2009.02.012
发表时间：
2009-01-01
影响因子：
7.2
作者：
Kim, H. J.;Figueroa, C. A.;Taylor, C. A.
通讯作者：
Taylor, C. A.
DOI：
10.1097/01.rvi.0000161144.98350.28
发表时间：
2005-06-01
影响因子：
2.9
作者：
Bax, L;Bakker, CJG;Mali, WPTRM
通讯作者：
Mali, WPTRM
影响因子：
--
作者：
GUYTON, JR;HARTLEY, CJ
通讯作者：
HARTLEY, CJ
DOI：
10.1016/j.cma.2005.11.011
发表时间：
2006-01-01
影响因子：
7.2
作者：
Figueroa, C. Alberto;Vignon-Clementel, Irene E.;Taylor, Charles A.
通讯作者：
Taylor, Charles A.
DOI：
10.1115/1.2354209
发表时间：
2006-12-01
影响因子：
1.7
作者：
Hoi, Yiemeng;Woodward, Scott H.;Meng, Hui
通讯作者：
Meng, Hui