The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons.
The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons.
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DOI：
10.1002/cne.22370
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发表时间：
2010-07-15
期刊：
影响因子：
--
通讯作者：
Jarvis ED
中科院分区：
文献类型：
--
作者：
Horita H;Wada K;Rivas MV;Hara E;Jarvis ED
许多立即早期基因（IEGs）在大脑亚群或神经元类型中具有活性依赖性诱导。然而，还没有报道与特定的调节丘脑受体感觉神经元的端脑或丘脑感觉输入神经元本身。在这里，我们报告了第一个这样的基因，双特异性磷酸酶1（dusp1）。Dusp 1是丝裂原活化蛋白激酶（MAPK）的灭活剂，MAPK激活egr 1的表达，egr 1是最常研究的IEG之一，如在培养细胞中测定的。我们发现，在自然行为鸣禽和其他鸟类的大脑中，听到歌声，看到视觉刺激，或执行运动行为分别导致丘脑的听觉，视觉和体感输入细胞群以及端脑苍白球的丘脑受体感觉神经元的dusp1高上调，而高的EGR 1上调仅发生在这些相同通路的随后连接的二级和三级感觉神经元群中。运动行为并没有诱导高水平的dusp1表达的运动相关区域附近的歌曲核，在那里egr 1是上调响应运动。我们对小鼠大脑中dusp1表达的分析表明，丘脑和丘脑受体层IV和VI皮层神经元的感觉输入神经元中存在类似的调节。这些发现表明，dusp1有专门的调节丘脑和端脑的感觉输入神经元，他们进一步表明，这种调节可能有助于减弱刺激诱导的egr 1和其他IEGs的表达，导致前脑感觉输入神经元的独特分子特性。
Many immediate early genes (IEGs) have activity-dependent induction in a subset of brain subdivisions or neuron types. However, none have been reported yet with regulation specific to thalamic-recipient sensory neurons of the telencephalon or in the thalamic sensory input neurons themselves. Here, we report the first such gene, dual specificity phosphatase 1 (dusp1). Dusp1 is an inactivator of mitogen-activated protein kinase (MAPK), and MAPK activates expression of egr1, one of the most commonly studied IEGs, as determined in cultured cells. We found that in the brain of naturally behaving songbirds and other avian species, hearing song, seeing visual stimuli, or performing motor behavior caused high dusp1 upregulation, respectively, in auditory, visual, and somatosensory input cell populations of the thalamus and thalamic-recipient sensory neurons of the telencephalic pallium, whereas high egr1 upregulation occurred only in subsequently connected secondary and tertiary sensory neuronal populations of these same pathways. Motor behavior did not induce high levels of dusp1 expression in the motor-associated areas adjacent to song nuclei, where egr1 is upregulated in response to movement. Our analysis of dusp1 expression in mouse brain suggests similar regulation in the sensory input neurons of the thalamus and thalamic-recipient layer IV and VI neurons of the cortex. These findings suggest that dusp1 has specialized regulation to sensory input neurons of the thalamus and telencephalon; they further suggest that this regulation may serve to attenuate stimulus-induced expression of egr1 and other IEGs, leading to unique molecular properties of forebrain sensory input neurons.
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影响因子：
3.7
作者：
Feenders, Gesa;Liedvogel, Miriam;Rivas, Miriam;Zapka, Manuela;Horita, Haruhito;Hara, Erina;Wada, Kazuhiro;Mouritsen, Henrik;Jarvis, Erich D.
通讯作者：
Jarvis, Erich D.
影响因子：
2.5
作者：
BENOWITZ, LI;KARTEN, HJ
通讯作者：
KARTEN, HJ
影响因子：
2.5
作者：
Cardin, JA;Raksin, JN;Schmidt, MF
通讯作者：
Schmidt, MF
影响因子：
2.8
作者：
Bisler, S;Schleicher, A;Staiger, JF
通讯作者：
Staiger, JF
影响因子：
1.7
作者：
Güntürkün, O;Hellmann, B;Prior, H
通讯作者：
Prior, H