Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation.
Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation.
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帕金森氏病，暴露于传染性剂和农药以及脑损伤的发生：神经炎症的作用。
DOI：
10.1289/ehp.6361
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发表时间：
2003-06
影响因子：
10.4
通讯作者：
Hong JS
中科院分区：
文献类型：
--
作者：
Liu B;Gao HM;Hong JS
特发性帕金森病（PD）是一种以黑质纹状体多巴胺能通路选择性变性为特征的破坏性运动障碍。神经变性通常在生命的第五个十年开始，并在达到完全症状性疾病状态之前进展5-10年。尽管经过数十年的深入研究，散发性PD的病因和选择性神经元丢失的机制仍然未知。然而，由于该病发病较晚，进展缓慢，因此人们考虑将环境中接触包括农药在内的农用化学品作为一个风险因素。此外，越来越多的证据表明，由于脑损伤或暴露于感染性病原体，脑中炎症的早期发生可能在PD的发病机制中起作用。最重要的是，可能有一个涉及脑免疫细胞（小胶质细胞和星形胶质细胞）的炎症过程的自我推进循环，驱动缓慢但渐进的神经退行性过程。破译这些复杂的相互作用的分子和细胞机制，将显着推进我们的病因和发病机制的PD的理解，并帮助发展的治疗策略，用于治疗疾病。
Idiopathic Parkinson's disease (PD) is a devastating movement disorder characterized by selective degeneration of the nigrostriatal dopaminergic pathway. Neurodegeneration usually starts in the fifth decade of life and progresses over 5-10 years before reaching the fully symptomatic disease state. Despite decades of intense research, the etiology of sporadic PD and the mechanism underlying the selective neuronal loss remain unknown. However, the late onset and slow-progressing nature of the disease has prompted the consideration of environmental exposure to agrochemicals, including pesticides, as a risk factor. Moreover, increasing evidence suggests that early-life occurrence of inflammation in the brain, as a consequence of either brain injury or exposure to infectious agents, may play a role in the pathogenesis of PD. Most important, there may be a self-propelling cycle of inflammatory process involving brain immune cells (microglia and astrocytes) that drives the slow yet progressive neurodegenerative process. Deciphering the molecular and cellular mechanisms governing those intricate interactions would significantly advance our understanding of the etiology and pathogenesis of PD and aid the development of therapeutic strategies for the treatment of the disease.
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影响因子：
4.7
作者：
Altschuler, E
通讯作者：
Altschuler, E
DOI：
10.1016/0922-4106(95)90083-7
发表时间：
1995-11-30
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
影响因子：
--
作者：
Bougria, M;Vitorica, J;Machado, A
通讯作者：
Machado, A
影响因子：
3.9
作者：
BECKMAN, JS;CROW, JP
通讯作者：
CROW, JP
影响因子：
4.4
作者：
Barron, KD
通讯作者：
Barron, KD
影响因子：
3.4
作者：
ALI, SF;CHANDRA, O;HASAN, M
通讯作者：
HASAN, M