Quantitative evaluation of posture control in rats with inferior olive lesions.
Quantitative evaluation of posture control in rats with inferior olive lesions.
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DOI：
10.1038/s41598-021-99785-w
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发表时间：
2021-10-13
影响因子：
4.6
通讯作者：
Yanagihara D
中科院分区：
文献类型：
--
作者：
Funato T;Sato Y;Sato Y;Fujiki S;Aoi S;Tsuchiya K;Yanagihara D
下橄榄核神经元（ION）的损伤会影响全身运动，并导致步态和姿势异常。由于离子是由不可预测的运动而不是有规律的身体运动激活的，因此离子损伤引起的姿势功能障碍预计涉及除了简单的反馈控制丧失之外的因素。在这项研究中，我们测量了大鼠的姿势运动与药理学离子病变（IO大鼠）训练站在他们的后肢。分析了人体各环节的协调性、质心运动的分布和频率特征。我们确定，病变改变了COM的功率谱密度的峰值特性，而协调和COM分布的变化是轻微的。为了研究观察到的属性如何反映控制系统的变化，我们构建了一个数学模型的站立大鼠和定量识别的控制系统。我们发现，增加线性比例控制和减少微分和非线性控制IO大鼠相比，完整的大鼠。身体刚度的肌张力障碍样变化解释了线性比例微分控制的性质，并且内部模型中的紊乱是非线性控制减少的一个可能原因。
Impairment of inferior olivary neurons (IONs) affects whole-body movements and results in abnormal gait and posture. Because IONs are activated by unpredicted motion rather than regular body movements, the postural dysfunction caused by ION lesions is expected to involve factors other than simple loss of feedback control. In this study, we measured the postural movements of rats with pharmacological ION lesions (IO rats) trained to stand on their hindlimbs. The coordination of body segments as well as the distribution and frequency characteristics of center of mass (COM) motion were analyzed. We determined that the lesion altered the peak properties of the power spectrum density of the COM, whereas changes in coordination and COM distribution were minor. To investigate how the observed properties reflected changes in the control system, we constructed a mathematical model of the standing rats and quantitatively identified the control system. We found an increase in linear proportional control and a decrease in differential and nonlinear control in IO rats compared with intact rats. The dystonia-like changes in body stiffness explain the nature of the linear proportional and differential control, and a disorder in the internal model is one possible cause of the decrease in nonlinear control.
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