The glia of Caenorhabditis elegans.
The glia of Caenorhabditis elegans.
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作者：
Oikonomou, Grigorios;Shaham, Shai
在很多方面，胶质细胞都是众所周知的房间里的大象。虽然神经胶质细胞和脊椎动物神经系统中的神经元一样多，但技术和其他方面的问题使对这些细胞的研究陷入困境，而对神经元的研究却在继续。重要的是，研究神经胶质细胞的模型系统远远落后。近年来，一个协调一致的努力，开发典型的无脊椎动物模型动物，果蝇和秀丽隐杆线虫，作为设置，以了解神经胶质细胞在神经系统发育和功能中的作用，已经开始取得成果。本文就胶质细胞及其在线虫神经系统中的作用进行综述。优美的我们描述的最近的研究突出了C。elegans和脊椎动物神经胶质细胞，并专注于新的见解，可能有普遍相关的所有神经系统。
Glia have been, in many ways, the proverbial elephant in the room. Although glia are as numerous as neurons in vertebrate nervous systems, technical and other concerns had left research on these cells languishing, while research on neurons marched on. Importantly, model systems to study glia had lagged considerably behind. A concerted effort in recent years to develop the canonical invertebrate model animals, Drosophila melanogaster and Caenorhabditis elegans, as settings to understand glial roles in nervous system development and function has begun to bear fruit. In this review we summarize our current understanding of glia and their roles in the nervous system of the nematode C. elegans. The recent studies we describe highlight the similarities and differences between C. elegans and vertebrate glia, and focus on novel insights that are likely to have general relevance to all nervous systems.
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影响因子：
2.5
作者：
Azevedo, Frederico A. C.;Carvalho, Ludmila R. B.;Herculano-Houzel, Suzana
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Herculano-Houzel, Suzana
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通讯作者：
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2.5
作者：
ALBERT, PS;RIDDLE, DL
通讯作者：
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