(Dys)regulation of Protein Metabolism in Skeletal Muscle of Humans With Obesity.
(Dys)regulation of Protein Metabolism in Skeletal Muscle of Humans With Obesity.
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肥胖人类骨骼肌蛋白质代谢的（异常）调节。
DOI：
10.3389/fphys.2022.843087
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发表时间：
2022
影响因子：
4
通讯作者：
Katsanos CS
中科院分区：
文献类型：
--
作者：
Freitas EDS;Katsanos CS
研究骨骼肌蛋白质组的研究提供了明确的证据，表明肥胖人群肌肉中的蛋白质代谢发生了改变。此外，肥胖人群的肌肉质量（即每单位肌肉质量的力量）似乎较低。然而，迄今为止描述肥胖人类肌肉中蛋白质周转（决定蛋白质含量和质量的过程）的相关证据非常不一致。这至少部分是由于肥胖人群骨骼肌蛋白质周转的异质性。尽管在混合肌肉蛋白质水平上并不总是明显，但肥胖人群肌肉中肌原纤维和线粒体蛋白质的合成率通常较低。此外，在刺激肌肉中蛋白质合成的条件下，包括进食状态、肌肉的血浆氨基酸可用性增加和运动，肥胖人类肌肉中蛋白质合成的改变更容易表现出来。目前的证据支持解释肥胖人类肌肉蛋白质合成受损的各种生物学机制，但这一证据相当有限，需要在更明确的实验条件下重现。通过直接测量肌肉中的蛋白质分解，更重要的是逐个蛋白质基础上的蛋白质周转，扩展我们目前的知识，将增强我们对肥胖如何改变肥胖人类肌肉中蛋白质组（含量和质量）的理解。
Studies investigating the proteome of skeletal muscle present clear evidence that protein metabolism is altered in muscle of humans with obesity. Moreover, muscle quality (i.e., strength per unit of muscle mass) appears lower in humans with obesity. However, relevant evidence to date describing the protein turnover, a process that determines content and quality of protein, in muscle of humans with obesity is quite inconsistent. This is due, at least in part, to heterogeneity in protein turnover in skeletal muscle of humans with obesity. Although not always evident at the mixed-muscle protein level, the rate of synthesis is generally lower in myofibrillar and mitochondrial proteins in muscle of humans with obesity. Moreover, alterations in the synthesis of protein in muscle of humans with obesity are manifested more readily under conditions that stimulate protein synthesis in muscle, including the fed state, increased plasma amino acid availability to muscle, and exercise. Current evidence supports various biological mechanisms explaining impairments in protein synthesis in muscle of humans with obesity, but this evidence is rather limited and needs to be reproduced under more defined experimental conditions. Expanding our current knowledge with direct measurements of protein breakdown in muscle, and more importantly of protein turnover on a protein by protein basis, will enhance our understanding of how obesity modifies the proteome (content and quality) in muscle of humans with obesity.
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影响因子：
4.8
作者：
Camera, Donny M.;Burniston, Jatin G.;Hawley, John A.
通讯作者：
Hawley, John A.
影响因子：
7.1
作者：
Beals, Joseph W.;Sukiennik, Richard A.;Burd, Nicholas A.
通讯作者：
Burd, Nicholas A.
影响因子：
3.4
作者：
Basisty N;Meyer JG;Schilling B
通讯作者：
Schilling B
DOI：
10.1152/ajpendo.1997.272.1.e94
发表时间：
1997-01-01
影响因子：
5.1
作者：
Butterfield, GE;Thompson, J;Hoffman, AR
通讯作者：
Hoffman, AR
DOI：
10.1016/j.ecl.2008.06.007
发表时间：
2008-09
影响因子：
4.5
作者：
Boden, Guenther
通讯作者：
Boden, Guenther