Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.
Neuropeptides and Behaviors: How Small Peptides Regulate Nervous System Function and Behavioral Outputs.
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DOI：
10.3389/fnmol.2021.786471
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发表时间：
2021
影响因子：
4.8
通讯作者：
Babu K
中科院分区：
文献类型：
--
作者：
Bhat US;Shahi N;Surendran S;Babu K
大多数多细胞动物生存和繁衍的原因之一是其神经系统的适应性和可塑性。对于有机体的生存，动物对环境变化做出反应和适应至关重要。这是通过感知外部线索并通过突触活动的变化将其转化为行为来实现的。神经系统在不断评估环境线索和实现生物体行为可塑性方面发挥着至关重要的作用。多种神经递质和神经肽被认为是整合感觉信息以产生所需输出的关键参与者。由于其简单的神经系统和完善的神经元连接组，秀丽隐杆线虫是理解行为可塑性背后机制的绝佳模型。在这里，我们批判性地回顾了神经肽如何通过允许神经元和突触信号的变化来调节广泛的行为。这篇综述将特别关注线虫的进食、交配、睡眠、成瘾、学习和运动行为。为了了解进化关系，我们探索了不同门中保守的秀丽隐杆线虫神经肽的功能和相关的病理生理学。此外，我们讨论了神经肽能信号传导的机制以及这些信号如何在不同的行为中受到调节。最后，我们试图深入探讨开发神经肽相关疾病的潜在疗法。
One of the reasons that most multicellular animals survive and thrive is because of the adaptable and plastic nature of their nervous systems. For an organism to survive, it is essential for the animal to respond and adapt to environmental changes. This is achieved by sensing external cues and translating them into behaviors through changes in synaptic activity. The nervous system plays a crucial role in constantly evaluating environmental cues and allowing for behavioral plasticity in the organism. Multiple neurotransmitters and neuropeptides have been implicated as key players for integrating sensory information to produce the desired output. Because of its simple nervous system and well-established neuronal connectome, C. elegans acts as an excellent model to understand the mechanisms underlying behavioral plasticity. Here, we critically review how neuropeptides modulate a wide range of behaviors by allowing for changes in neuronal and synaptic signaling. This review will have a specific focus on feeding, mating, sleep, addiction, learning and locomotory behaviors in C. elegans. With a view to understand evolutionary relationships, we explore the functions and associated pathophysiology of C. elegans neuropeptides that are conserved across different phyla. Further, we discuss the mechanisms of neuropeptidergic signaling and how these signals are regulated in different behaviors. Finally, we attempt to provide insight into developing potential therapeutics for neuropeptide-related disorders.
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影响因子：
3.7
作者：
Buntschuh, Ingrid;Raps, Daniel A.;Li, Chris
通讯作者：
Li, Chris
DOI：
10.1080/21624054.2015.1062971
发表时间：
2015-07
期刊：
Worm
影响因子：
--
作者：
Bhattacharya R;Francis MM
通讯作者：
Francis MM
影响因子：
25
作者：
Barrios, Arantza;Ghosh, Rajarshi;Fang, Chunhui;Emmons, Scott W.;Barr, Maureen M.
通讯作者：
Barr, Maureen M.
传入的神经肽系统会传输机械感觉信号，从而触发敏感性和秀丽隐杆线虫的唤醒。
影响因子：
16.2
作者：
Chew YL;Tanizawa Y;Cho Y;Zhao B;Yu AJ;Ardiel EL;Rabinowitch I;Bai J;Rankin CH;Lu H;Beets I;Schafer WR
通讯作者：
Schafer WR
影响因子：
3.7
作者：
Chang YJ;Burton T;Ha L;Huang Z;Olajubelo A;Li C
通讯作者：
Li C