Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
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DOI：
10.1038/nature08185
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发表时间：
2009-08-06
期刊：
影响因子：
64.8
通讯作者：
Sklar P
中科院分区：
文献类型：
--
作者：
International Schizophrenia Consortium;Purcell SM;Wray NR;Stone JL;Visscher PM;O'Donovan MC;Sullivan PF;Sklar P
精神分裂症（SCZ）是一种严重的精神障碍，终生风险约为1%，其特征是幻觉，妄想和认知缺陷，遗传率估计高达80%。我们采用了两种分析方法来确定常见遗传变异在多大程度上构成SCZ风险的基础，使用全基因组关联研究（GWAS）数据，来自3，322名SCZ欧洲个体和3，587名对照。首先，我们涉及主要组织相容性复合体（MHC）。第二，我们提供了分子遗传学证据，大量的多基因成分的风险SCZ涉及成千上万的常见等位基因的影响很小。我们发现，这一成分也有助于双相情感障碍（BPD）的风险，但不是多种非精神疾病。
Schizophrenia (SCZ) is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits with heritability estimated at up to 80%. We adopted two analytic approaches to determine the extent to which common genetic variation underlies risk of SCZ using genome-wide association study (GWAS) data from 3,322 European individuals with SCZ and 3,587 controls. First, we implicate the major histocompatibility complex (MHC). Second, we provide molecular genetic evidence for a substantial polygenic component to risk of SCZ involving thousands of common alleles of very small effect. We show that this component also contributes to risk of bipolar disorder (BPD), but not to multiple non-psychiatric diseases.
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影响因子：
7
作者：
Wray, Naomi R.;Goddard, Michael E.;Visscher, Peter M.
通讯作者：
Visscher, Peter M.
影响因子：
--
作者：
Sullivan, PF;Kendler, KS;Neale, MC
通讯作者：
Neale, MC
影响因子：
64.8
作者：
Stone, Jennifer L.;O'Donovan, Michael C.;Gurling, Hugh;Kirov, George K.;Blackwood, Douglas H. R.;Corvin, Aiden;Craddock, Nick J.;Gill, Michael;Hultman, Christina M.;Lichtenstein, Paul;McQuillin, Andrew;Pato, Carlos N.;Ruderfer, Douglas M.;Owen, Michael J.;St Clair, David;Sullivan, Patrick F.;Sklar, Pamela;Purcell, Shaun M.;Scolnick, E. M.;Holmans, P. A.;Georgieva, L.;Nikolov, I.;Norton, N.;Williams, H.;Williams, N. M.;Toncheva, D.;Milanova, V.;Thelander, E. F.;Morris, D. W.;O'Dushlaine, C. T.;Kenny, E.;Waddington, J. L.;Choudhury, K.;Datta, S.;Pimm, J.;Thirumalai, S.;Puri, V.;Krasucki, R.;Lawrence, J.;Quested, D.;Bass, N.;Curtis, D.;Crombie, C.;Fraser, G.;Kwan, S. L.;Muir, W. J.;McGhee, K. A.;Pickard, B.;Malloy, P.;Maclean, A. W.;Van Beck, M.;Visscher, P. M.;Macgregor, S.;Pato, M. T.;Medeiros, H.;Middleton, F.;Carvalho, C.;Morley, C.;Fanous, A.;Conti, D.;Knowles, J. A.;Ferreira, C. P.;Azevedo, M. H.;McCarroll, S. A.;Gates, C.;Daly, M. J.;Sklar, P.
通讯作者：
Sklar, P.
影响因子：
6.6
作者：
Craddock, N;O'Donovan, MC;Owen, MJ
通讯作者：
Owen, MJ
影响因子：
30.8
作者：
O'Donovan, Michael C.;Craddock, Nicholas;Owen, Michael J.
通讯作者：
Owen, Michael J.