In vivo high-resolution magnetic resonance skin imaging at 1.5 T and 3 T.
In vivo high-resolution magnetic resonance skin imaging at 1.5 T and 3 T.
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DOI：
10.1002/mrm.22271
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发表时间：
2010-03
影响因子：
3.3
通讯作者：
Nishimura, Dwight G.
中科院分区：
文献类型：
--
作者：
Barral, Joelle K.;Bangerter, Neal K.;Hu, Bob S.;Nishimura, Dwight G.
作为一种非侵入性的模态，MR对于在体皮肤成像是有吸引力的。其独特的软组织对比度使其成为研究皮肤含水量和分辨不同皮肤层的理想成像模式。在这项工作中，在体内高分辨率皮肤成像的挑战得到解决。三个三维笛卡尔序列定制，以实现高分辨率成像和各自的性能进行评估。平衡稳态自由旋进（bSSFP）和梯度回波（GRE）速度快，但对非共振伪影敏感。快速大角度自旋回波（FLASE）提供了对皮下组织结构的清晰描绘，但产生更高的比吸收率（SAR）。评估了增加场强的效果。与1.5 T相比，3 T下的信噪比（SNR）在皮下组织中略有增加，在真皮中几乎增加一倍。脂肪/水分离的需要是公认的，并使用交错三点狄克逊方法和迭代重建的解决方案被证明是有效的。运动的影响进行了分析，并评估了两种技术，以防止运动和纠正它。成像时间小于6 min，获得117 × 117 × 500 µm3分辨率的图像。
As a non-invasive modality, MR is attractive for in vivo skin imaging. Its unique soft tissue contrast makes it an ideal imaging modality to study the skin water content and to resolve the different skin layers. In this work, the challenges of in vivo high-resolution skin imaging are addressed. Three 3D Cartesian sequences are customized to achieve high-resolution imaging and their respective performance is evaluated. Balanced Steady State Free Precession (bSSFP) and GRadient Echo (GRE) are fast but can be sensitive to off-resonance artifacts. Fast Large Angle Spin Echo (FLASE) provides a sharp depiction of the hypodermis structures, but results in more Specific Absorption Rate (SAR). The effect of increasing the field strength is assessed. As compared to 1.5 T, Signal-to-Noise Ratio (SNR) at 3 T slightly increases in the hypodermis and almost doubles in the dermis. The need for fat/water separation is acknowledged and a solution using an interleaved three-point Dixon method and an iterative reconstruction is shown to be effective. The effects of motion are analyzed and two techniques to prevent motion and correct for it are evaluated. Images with 117 × 117 × 500 µm3 resolution are obtained in imaging times under 6 min.
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影响因子：
3.3
作者：
Bangerter, NK;Hargreaves, BA;Nishimura, DG
通讯作者：
Nishimura, DG
影响因子：
3.3
作者：
Magland, J. F.;Wald, M. J.;Wehrli, F. W.
通讯作者：
Wehrli, F. W.
影响因子：
2.2
作者：
Pennasilico, GM;Arcuri, PP;Falappa, P
通讯作者：
Falappa, P
影响因子：
5.9
作者：
Aubry, Sebastien;Casile, Celine;Kastler, Bruno
通讯作者：
Kastler, Bruno
影响因子：
2.2
作者：
Mirrashed, F;Sharp, JC
通讯作者：
Sharp, JC