Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.
Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.
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DOI：
10.1038/ncomms2886
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
尽管利用纳米技术提供广泛的医疗治疗有可能减少与药物治疗相关的不良反应，但针对组织的治疗仍然具有挑战性。在这里，我们展示了由葡萄柚衍生的脂类制成的纳米颗粒，我们称之为葡萄柚衍生纳米载体(GNV)，可以将化疗药物、siRNA、DNA表达载体和蛋白质运送到不同类型的细胞。我们通过与叶酸共同递送治疗剂来证明GNV的体内靶向性，这反过来又导致显著提高对表达叶酸受体的细胞的靶向效率。在两种肿瘤动物模型中，通过增强化疗对肿瘤生长的抑制，进一步证明了GNV的治疗潜力。GNV的毒性低于由合成脂质制成的纳米颗粒，而且当静脉注射到怀孕小鼠体内时，它们不会通过胎盘屏障，这表明它们可能是一种有用的药物输送工具。
Although the use of nanotechnology for the delivery of a wide range of medical treatments has potential to reduce adverse effects associated with drug therapy, tissue-specific delivery remains challenging. Here we show that nanoparticles made of grapefruit-derived lipids, which we call grapefruit-derived nanovectors (GNVs), can transport chemotherapeutic agents, siRNA, DNA expression vectors and proteins to different types of cells. We demonstrate the in vivo targeting specificity of GNVs by co-delivering therapeutic agents with folic acid, which in turn leads to significantly increasing targeting efficiency to cells expressing folate receptors. The therapeutic potential of GNVs was further demonstrated by enhancing the chemotherapeutic inhibition of tumor growth in two tumor animal models. GNVs are less toxic than nanoparticles made of synthetic lipids and, when injected intravenously into pregnant mice, do not pass the placental barrier, suggesting they may be a useful tool for drug delivery.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1016/j.jconrel.2012.07.010
发表时间：
2012-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Kwon IK;Lee SC;Han B;Park K
通讯作者：
Park K
影响因子：
4.5
作者：
Mayer, Andrea;Vadon, Maria;Froehlich, Eleonore
通讯作者：
Froehlich, Eleonore
影响因子：
29.4
作者：
Nguyen, TT;Dyer, DL;Said, HM
通讯作者：
Said, HM
影响因子：
3.8
作者：
Spilman, Michael S.;Welbon, Craig;Dokland, Terje
通讯作者：
Dokland, Terje