Gap Effect Abnormalities during a Visually Guided Pro-Saccade Task in Children with Attention Deficit Hyperactivity Disorder.
Gap Effect Abnormalities during a Visually Guided Pro-Saccade Task in Children with Attention Deficit Hyperactivity Disorder.
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DOI：
10.1371/journal.pone.0125573
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kitamura Y
中科院分区：
文献类型：
--
作者：
Matsuo Y;Watanabe M;Taniike M;Mohri I;Kobashi S;Tachibana M;Kobayashi Y;Kitamura Y
注意力缺陷多动障碍（ADHD）是一种神经发育障碍，始于儿童早期，对心理社会活动和教育以及整个生命周期的一般健康产生全面影响。尽管它的患病率，目前的诊断标准为ADHD的争论。扫视眼球运动很容易量化，可能是各种神经和精神疾病（包括ADHD）的定量生物标志物。本研究的目的是检查ADHD儿童在视觉引导的亲扫视眼球运动过程中是否表现出异常，并阐明与其行为障碍相关的神经生理机制。37名ADHD儿童（5-11岁）和88名正常发育（TD）儿童（5-11岁）被要求执行一项简单的扫视眼动任务，其中步骤和间隙条件随机交错。我们评估了差距效应，这是两种条件之间反应时间的差异。ADHD儿童的反应时显著长于TD儿童（p < 0.01），且差距效应显著减弱（p < 0.01）。这些结果表明，扫视眼动的测量可能为评价ADHD的行为症状和临床特征提供一种新的方法，差距效应可能是儿童早期ADHD诊断的潜在生物标志物。
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that starts in early childhood and has a comprehensive impact on psychosocial activity and education as well as general health across the lifespan. Despite its prevalence, the current diagnostic criteria for ADHD are debated. Saccadic eye movements are easy to quantify and may be a quantitative biomarker for a wide variety of neurological and psychiatric disorders, including ADHD. The goal of this study was to examine whether children with ADHD exhibit abnormalities during a visually guided pro-saccadic eye-movement and to clarify the neurophysiological mechanisms associated with their behavioral impairments. Thirty-seven children with ADHD (aged 5–11 years) and 88 typically developing (TD) children (aged 5–11 years) were asked to perform a simple saccadic eye-movement task in which step and gap conditions were randomly interleaved. We evaluated the gap effect, which is the difference in the reaction time between the two conditions. Children with ADHD had a significantly longer reaction time than TD children (p < 0.01) and the gap effect was markedly attenuated (p < 0.01). These results suggest that the measurement of saccadic eye movements may provide a novel method for evaluating the behavioral symptoms and clinical features of ADHD, and that the gap effect is a potential biomarker for the diagnosis of ADHD in early childhood.
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影响因子：
9.2
作者：
Carpenter, RHS
通讯作者：
Carpenter, RHS
影响因子：
3.2
作者：
Dorris, MC;Klein, RM;Munoz, DP
通讯作者：
Munoz, DP
DOI：
10.1207/s15374424jccp3004_06
发表时间：
2001-12-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
Biederman, J;Monuteaux, MC;Faraone, SV
通讯作者：
Faraone, SV
影响因子：
1.7
作者：
Fukushima, J;Hatta, T;Fukushima, K
通讯作者：
Fukushima, K
DOI：
10.1046/j.1440-1614.2001.00923.x
发表时间：
2001-08-01
影响因子：
4.6
作者：
Levy, F;Swanson, JM
通讯作者：
Swanson, JM