Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls.
Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls.
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DOI：
10.1002/da.20506
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发表时间：
2009
影响因子：
7.4
通讯作者：
Foa, Edna B.
中科院分区：
文献类型：
--
作者：
Huppert, Jonathan D.;Simpson, H. Blair;Nissenson, Kore J.;Liebowitz, Michael R.;Foa, Edna B.
一些研究表明，强迫症（OCD）与生活质量干扰（QOL）和功能障碍有关。然而，这些研究并没有比较缓解的个体和继续患有这种疾病的个体，主要使用与规范的比较，而不是与匹配的正常样本进行比较，并且并不总是考虑合并症的影响。我们对66名先前同意进行临床试验的强迫症患者和36名年龄和性别匹配的否认有任何精神病史的个体进行了多种测量，以评估生活质量和功能损害。结果证实，与健康对照组相比，强迫症患者在工作、社会生活和家庭生活方面的生活质量和功能损害显著降低。患有强迫症和其他共病精神诊断的个体表现出最差的生活质量和功能，其中共病抑郁症占了大部分差异。缓解期个体的生活质量和功能水平往往介于健康对照组和当前强迫症患者之间：他们的生活质量和功能与健康对照组没有显著差异，与当前强迫症患者也没有显著差异。这些结果表明，处于缓解期的个体的生活质量和功能水平有所改善，而患有强迫症的个体则明显受损，并且患有强迫症和合并症的个体受损最严重。治疗策略应侧重于实现所有症状的缓解，以便对功能和生活质量产生最大的影响。
Several studies have demonstrated that obsessive-compulsive disorder (OCD) is associated with interference in quality of life (QOL) and functional impairment. However, these studies did not compare individuals in remission to individuals who continue to have the disorder, predominantly used comparisons with norms and not with a matched normal sample, and did not always consider the impact of comorbidity. We administered multiple measures that assess QOL and functional impairment to 66 OCD patients who had previously consented for a clinical trial, and to 36 age and sex matched individuals who denied any psychiatric history. Results confirm that OCD was associated with significantly lower QOL and functional impairment compared to healthy controls in areas of work, social life, and family life. Individuals with OCD and other comorbid psychiatric diagnoses showed the poorest QOL and functioning, with comorbid depression accounting for much of the variance. The levels of QOL and functioning in individuals in remission tended to lay in between healthy controls and individuals with current OCD: their QOL or functioning did not differ significantly from healthy controls, nor did they consistently differ significantly from who had current OCD. These results suggest that individuals who are in remission have improved levels of QOL and functioning while individuals with OCD are significantly impaired, and individuals with OCD and comorbid disorders are the most impaired. Treatment strategies should be focused on achieving remission of all symptoms in order to have the greatest impact on functioning and QOL.
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影响因子：
3.6
作者：
Foa, EB;Huppert, JD;Salkovskis, PM
通讯作者：
Salkovskis, PM
影响因子：
10.3
作者：
Huppert, Jonathan D.;Walther, Michael R.;Liebowitz, Michael R.
通讯作者：
Liebowitz, Michael R.
影响因子：
22.8
作者：
Mataix-Cols, D;Marks, IM;Baer, L
通讯作者：
Baer, L
影响因子：
3
作者：
MCHORNEY, CA;WARE, JE;RACZEK, AE
通讯作者：
RACZEK, AE
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE