The treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Review.
The treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Review.
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不宁腿综合征和周期性肢体运动障碍的治疗。
作者：
W. Hening;R. Allen;C. Earley;C. Kushida;D. Picchietti;M. Silber
一个由六名作者组成的工作组回顾了1998年4月之前发表的关于不宁腿综合征或睡眠中周期性肢体运动的治疗文献。他们选择了45篇文章进行详细的审查，这些文章都是对不宁腿综合征（RLS）或周期性肢体运动（PLM）的治疗效果进行了原始研究，并且符合最低标准。这些文章涉及一系列药理学和其他治疗方式，尽管大多数涉及药物治疗，其中几乎一半集中在多巴胺能药物上，特别是各种配方的左旋多巴。几乎有一半的文章使用了对照方法，最常见的是随机分配受试者的交叉方法。未发现有大量受试者的多中心研究和长期对照研究。从文献中提取信息，将研究设计、临床定义、评价指标、副作用和结局列在6个证据表中，并在随附的文本中进行总结。本文献对所进行研究的性质及其对潜在治疗方法的覆盖范围进行了评估。本文总结了基于文献现状的治疗性研究可能的未来方向。
A task force consisting of six authors reviewed the published literature on the therapy of the restless legs syndrome or periodic limb movements in sleep available in indices through April, 1998. They selected the 45 articles for detailed review which presented original investigations of therapeutic impact on the restless legs syndrome (RLS) or periodic limb movements (PLM) and which met minimal standards. These articles dealt with a range of pharmacological and other treatment modalities, although most dealt with medications and almost half of those concentrated on dopaminergic agents, especially levodopa in various formulations. Almost half of the articles reviewed used controlled methodologies, most commonly cross-over methodologies with randomized allocation of subjects. Multi-center studies with large numbers of subjects and long-term controlled studies were not found. Information was extracted from the articles and study design, clinical definition, evaluative measures, side effects, and outcomes were tabulated in 6 evidence tables and summarized in the accompanying text. This literature was evaluated for the nature of the studies performed and its coverage of potential therapies. The review concludes with comments on possible future directions for therapeutic investigation based on the current state of the literature.
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影响因子：
5.6
作者：
Dickel,MJ;Mosko,SS
通讯作者：
Mosko,SS
老年人群中的睡眠呼吸暂停和夜间肌阵挛。
影响因子：
5.6
作者：
Ancoli-Israel,S;Kripke,DF;Mason,W;Messin,S
通讯作者：
Messin,S
认知行为疗法与氯硝西泮治疗周期性肢体运动障碍的比较。
影响因子：
5.6
作者：
Edinger,JD;Fins,AI;Sullivan,RJ;Marsh,GR;Dailey,DS;Young,M
通讯作者：
Young,M
夜间肌阵挛：氯硝西泮和替马西泮的治疗效果。
影响因子：
5.6
作者：
Mitler,MM;Browman,CP;Menn,SJ;Gujavarty,K;Timms,RM
通讯作者：
Timms,RM