Killing two birds with one stone: trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria.
Killing two birds with one stone: trans-kingdom suppression of PAMP/MAMP-induced immunity by T3E from enteropathogenic bacteria.
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用一块石头杀死两只鸟：T3E从肠病细菌中抑制PAMP/MAMP诱导的免疫力。
DOI：
10.3389/fmicb.2014.00320
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发表时间：
2014
影响因子：
5.2
通讯作者：
Brunner F
中科院分区：
文献类型：
--
作者：
Fraiture M;Brunner F
在过去的十年中，动物和植物系统的非自我识别的分子组织之间的显着相似性被揭示出来。介导病原体或微生物相关分子模式识别的受体（PAMPs/MAMPs）的分子结构与植物模式识别受体之间存在明显的相似之处，所述植物模式识别受体与哺乳动物Toll样受体非常相似。丝裂原活化的蛋白激酶级联反应，导致免疫相关基因的转录激活，说明了PAMP/MAMP诱导的信号转导的整个分子构件的保守性。致病性沙门氏菌和大肠杆菌使用第三型分泌系统（T3 SS）将效应蛋白注入哺乳动物宿主细胞以破坏防御机制并促进肠道感染。最近，疾病的发生越来越多地与细菌污染的水果和蔬菜有关，并且关于效应物是否以及如何以跨王国的方式靶向先天免疫反应已经出现了共同的主题。我们建议，许多沙门氏菌或E。大肠杆菌效应子可能在植物中具有活性，并且倾向于靶向免疫信号传导途径的中心组分（枢纽）。
Within the past decade, remarkable similarities between the molecular organization of animal and plant systems for non-self discrimination were revealed. Obvious parallels exist between the molecular structures of the receptors mediating the recognition of pathogen- or microbe-associated molecular patterns (PAMPs/MAMPs) with plant pattern recognition receptors strikingly resembling mammalian Toll-like receptors. Mitogen-activated protein kinase cascades, leading to the transcriptional activation of immunity-associated genes, illustrate the conservation of whole molecular building blocks of PAMP/MAMP-induced signaling. Enteropathogenic Salmonella and Escherichia coli use a type three secretion system (T3SS) to inject effector proteins into the mammalian host cell to subvert defense mechanisms and promote gut infection. Lately, disease occurrence was increasingly associated with bacteria-contaminated fruits and vegetables and common themes have emerged with regard to whether and how effectors target innate immune responses in a trans-kingdom manner. We propose that numerous Salmonella or E. coli effectors may be active in planta and tend to target central components (hubs) of immune signaling pathways.
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影响因子：
6.7
作者：
Bruno VM;Hannemann S;Lara-Tejero M;Flavell RA;Kleinstein SH;Galán JE
通讯作者：
Galán JE
影响因子：
64.8
作者：
Chinchilla, Delphine;Zipfel, Cyril;Boller, Thomas
通讯作者：
Boller, Thomas
影响因子：
30.5
作者：
Ausubel, FM
通讯作者：
Ausubel, FM
影响因子：
16
作者：
Kadota, Yasuhiro;Sklenar, Jan;Zipfel, Cyril
通讯作者：
Zipfel, Cyril
影响因子：
64.8
作者：
Asai, T;Tena, G;Sheen, J
通讯作者：
Sheen, J