Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study.
Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study.
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DOI：
10.1007/s10552-010-9514-9
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发表时间：
2010-06
影响因子：
2.3
通讯作者：
Alavanja, Michael C. R.
中科院分区：
文献类型：
--
作者：
Bonner, Matthew R.;Williams, Brent A.;Rusiecki, Jennifer A.;Blair, Aaron;Freeman, Laura E. Beane;Hoppin, Jane A.;Dosemeci, Mustafa;Lubin, Jay;Sandler, Dale P.;Alavanja, Michael C. R.
Terbufos是美国第四大常用的有机磷杀虫剂（OP）。特布福尚未被证明对啮齿动物具有致癌性，尽管在流行病学研究中，包括有机磷农药在内的非砷杀虫剂与过量癌症有关。我们调查了使用特布福与癌症发病率之间的关系。农业健康研究是一项前瞻性队列研究，研究对象包括来自爱荷华州和北卡罗来纳州的57,310名持牌农药施用者。从自我填写的问卷中获得了50种农药（包括terbufos）和潜在混杂物的详细信息。Terbufos强度加权终生暴露-天数[（终生暴露-天数）X（暴露强度评分）]。病例包括入组至2005年12月31日期间诊断出的所有原发性癌症。采用Cox比例风险模型计算风险比（HR）和95% CI，调整潜在混杂因素。terbufos使用者的总体癌症风险略有增加（HR 1.21(1.06-1.37)）。虽然暴露-反应梯度是非单调的，趋势的p值也不显著，但在大丁胺素的使用和前列腺癌（最高比值= 1.21,95% CI = 0.99-1.47）、肺癌（中间比值= 1.45,95% CI = 0.95-2.22）、白血病（中间比值= 2.38,95% CI = 1.35-4.21）和非霍奇金淋巴瘤（中间比值= 1.94,95% CI = 1.16-3.22）之间存在提示关联。我们发现在职业性使用terbufos和一些癌症部位之间存在暗示性的联系。然而，对这些结果的谨慎解释是必要的，因为缺乏现有的实验和流行病学证据来支持特布福的致癌作用。
Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and incidence of cancer. The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days [(lifetime exposure-days) X (exposure intensity score)]. Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders. Overall cancer risk was slightly increased among terbufos users (HR 1.21 (1.06-1.37). Suggestive associations were observed between terbufos use and cancers of the prostate (HR highest tertile = 1.21; 95% CI = 0.99-1.47) and lung (HR middle tertile = 1.45; 95% CI = 0.95-2.22) and leukemia (HR middle tertile = 2.38; 95% CI = 1.35-4.21) and non-Hodgkin lymphoma (HR middle tertile = 1.94; 95% CI = 1.16-3.22), although the exposure-response gradients were non-monotonic and p for trends were not significant. We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos.
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影响因子：
6.4
作者：
Andreotti, Gabriella;Freeman, Laura E. Beane;Hou, Lifang;Coble, Joseph;Rusiecki, Jennifer;Hoppin, Jane A.;Silverman, Debra T.;Alavanja, Michael C. R.
通讯作者：
Alavanja, Michael C. R.
影响因子：
10.4
作者：
Cabello, G;Valenzuela, M;Calaf, G
通讯作者：
Calaf, G
影响因子：
4.5
作者：
Bagchi, D;Bagchi, M;Stohs, SJ
通讯作者：
Stohs, SJ
DOI：
10.1038/sj.jea.7500232
发表时间：
2002-09-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Hoppin, JA;Yucel, F;Sandler, DP
通讯作者：
Sandler, DP
DOI：
10.1016/0165-1218(82)90161-6
发表时间：
1982-01-01
期刊：
MUTATION RESEARCH
影响因子：
--
作者：
GENTILE, JM;GENTILE, GJ;PLEWA, MJ
通讯作者：
PLEWA, MJ