Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort.
Agricultural pesticide use and pancreatic cancer risk in the Agricultural Health Study Cohort.
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DOI：
10.1002/ijc.24185
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发表时间：
2009-05-15
影响因子：
6.4
通讯作者：
Alavanja, Michael C. R.
中科院分区：
文献类型：
--
作者：
Andreotti, Gabriella;Freeman, Laura E. Beane;Hou, Lifang;Coble, Joseph;Rusiecki, Jennifer;Hoppin, Jane A.;Silverman, Debra T.;Alavanja, Michael C. R.
胰腺癌是一种快速致命的疾病，与农药的使用有关。以前的研究已经报道了有机氯如滴滴涕的胰腺癌风险过高，然而，许多其他常用的农药尚未进行研究。为了进一步研究使用多种农药与胰腺癌之间的潜在关联，我们在农业健康研究中进行了病例对照分析，这是最大的前瞻性队列之一，有超过89，000名参与者，包括爱荷华州和北卡罗来纳州的农药施用者及其配偶。这项分析包括93例胰腺癌病例（64名施用者，29名配偶）和82，503名无癌症对照，他们完成了一份登记问卷，提供了详细的农药使用，人口统计学和生活方式信息。评价了24种农药的使用史和13种农药的强度加权寿命天数[（寿命暴露天数）×（暴露强度评分）]。风险评估采用控制年龄、吸烟和糖尿病的非条件logistic回归进行计算。在农药施用者中，对13种农药进行强度加权终身使用检查的两种除草剂（EPTC和二甲戊灵）显示出与胰腺癌具有统计学显著的安全反应相关性。与从不使用者相比，使用二甲戊灵的前半部分的施用者的风险为3.0倍（95% CI 1.3-7.2，p趋势=0.01），与从不使用者相比，使用EPTC的前半部分的施用者的风险为2.56倍（95% CI=1.1-5.4，p趋势=0.01）。在这项研究中，有机氯与胰腺癌的过度风险无关。这些发现表明，除草剂，特别是二甲戊灵和EPTC，可能与胰腺癌有关。
Pancreatic cancer is a rapidly fatal disease that has been linked with pesticide use. Previous studies have reported excess risks of pancreatic cancer with organochlorines such as DDT, however, many other commonly used pesticides have not been examined. To further examine the potential associations between the use of a number of pesticides and pancreatic cancer, we conducted a case-control analysis in the Agricultural Health Study, one of the largest prospective cohorts with over 89,000 participants including pesticide applicators and their spouses in Iowa and North Carolina. This analysis included 93 incident pancreatic cancer cases (64 applicators, 29 spouses) and 82,503 cancer-free controls who completed an enrollment questionnaire providing detailed pesticide use, demographic and lifestyle information. Ever use of 24 pesticides and intensity-weighted lifetime days [(lifetime exposure days) × (exposure intensity score)] of 13 pesticides was assessed. Risk estimates were calculated using unconditional logistic regression controlling for age, smoking, and diabetes. Among pesticide applicators, two herbicides (EPTC and pendimethalin) of the 13 pesticides examined for intensity-weighted lifetime use showed a statistically significant exposure-response association with pancreatic cancer. Applicators in the top half of lifetime pendimethalin use had a 3.0-fold (95% CI 1.3-7.2, p-trend=0.01) risk compared to never users, and those in the top half of lifetime EPTC use had a 2.56-fold (95% CI=1.1-5.4, p-trend=0.01) risk compared to never users. Organochlorines were not associated with an excess risk of pancreatic cancer in this study. These findings suggest that herbicides, particularly pendimethalin and EPTC, may be associated with pancreatic cancer.
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DOI：
10.1097/00043764-200107000-00012
发表时间：
2001-07-01
影响因子：
3.2
作者：
Zheng, TZ;Zahm, SH;Blair, A
通讯作者：
Blair, A
DOI：
10.1093/jnci/84.10.764
发表时间：
1992-05-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
GARABRANT, DH;HELD, J;MACK, TM
通讯作者：
MACK, TM
影响因子：
5.4
作者：
Hou, LF;Lee, WJ;Alavanja, MCR
通讯作者：
Alavanja, MCR
影响因子：
10.3
作者：
SILVERMAN, DT;DUNN, JA;POTTERN, LM
通讯作者：
POTTERN, LM
影响因子：
5
作者：
Alavanja, MCR;Dosemeci, M;Blair, A
通讯作者：
Blair, A